Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: o-Phthalaldehyde
CAS Number: 643-79-8
Alias: OPA, 1,2-Benzenedicarboxaldehyde, Orthophthalaldehyde
Chemical Full Name: benzene-1,2-dicarbaldehyde
Molecular Formula: C8H6O2
Molecular Weight: 134.13
EINECS: 211-402-2
Structural Information
- Structure Type: Aromatic dialdehyde fine chemical analytical reagent intermediate
- Structural Features: Benzene ring with two adjacent aldehyde groups; highly reactive with primary amines under alkaline conditions to form fluorescent isoindole derivatives; strong cross-linking and bactericidal activity
- Characteristic: Core fluorescent derivatization reagent for amino acid detection, high-efficiency medical disinfectant raw material
Physical & Chemical Properties
- Appearance: White to pale yellow crystalline powder
- Odor: Pungent irritating aldehyde odor
- Melting Point: 54–56 °C
- Boiling Point: Decomposes on heating
- Density (20℃): 1.13 g/cm3
- Solubility: Slightly soluble in water; soluble in ethanol, methanol, acetonitrile, chloroform, DMSO
- Stability: Unstable under light and air; easily oxidized to phthalic acid; reacts with amines, alcohols, nucleophiles; avoid long-term exposure to sunlight
Synthesis & Applications
Production Method
Oxidation of o-xylene or hydrolysis of o-phthalic tetrachloride, recrystallization purification.
Main Applications
- Analytical chemistry reagent: Fluorescent derivatization agent for HPLC detection of amino acids, peptides, biogenic amines
- Medical high-level disinfectant: Rapid sterilization raw material for endoscope disinfection, low corrosion compared with glutaraldehyde
- Organic synthesis intermediate: Cross-linking agent for protein immobilization, heterocyclic compound synthetic building block
- Biochemical research: Fluorescent labeling reagent for protein and amine biomolecules
Safety & Storage Instructions
GHS Hazard Classification
- H315 Causes skin irritation
- H317 May cause allergic skin reaction
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation from dust/vapor inhalation
Personal Protection
Dust respirator, full-face chemical splash goggles, nitrile impermeable gloves, protective overalls; operate in fume hood to avoid aldehyde vapor inhalation.
Storage Condition
Hermetically sealed light-proof cardboard drum lined with PE film, cool dry warehouse ≤25℃; isolate oxidants, amines, alcohols, strictly shield from sunlight to prevent oxidation degradation.
Transportation
General irritating fine chemical solid powder; light-proof and moisture-proof packaging, separated from food and amine chemicals during transit.
Quality Specifications
- Purity (HPLC): ≥99.0%
- Loss on Drying: ≤0.3%
- Residue on Ignition: ≤0.1%
- Single impurity: ≤0.1%
Information Summary Table
| Item | Specification |
| CAS Number | 643-79-8 |
| Product Name | o-Phthalaldehyde (OPA) |
| Synonym | 1,2-Benzenedicarboxaldehyde |
| Molecular Formula | C8H6O2 |
| Molecular Weight | 134.13 |
| Appearance | White crystalline powder |
| Melting Point | 54–56℃ |
| Core Advantage | Fluorescent derivatization reagent for amino acid analysis, low-corrosion endoscope disinfectant raw material |
| Storage Rule | Light-proof sealed low-temperature storage, away from amines and oxidants |
| Hazard Property | Skin sensitizer, irritates eyes, skin and respiratory tract |
| Main Usage | HPLC amino acid fluorescent reagent, medical endoscopic disinfectant, protein cross-linking agent |
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