Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
Basic Information
Product Name: Denatonium benzoate
CAS Number: 3734-33-6
Alias: Bitrex, Benzyldiethyl[(2,6-dimethylphenyl)carbamoylmethyl]ammonium benzoate
Chemical Full Name: benzyl(diethyl)[(2,6-dimethylphenyl)carbamoylmethyl]azanium benzoate
Molecular Formula: C??H??N?O?
Molecular Weight: 446.58
EINECS: 223-095-2
Structural Information
- Structure Type: Quaternary ammonium bittering agent fine chemical
- Structural Features: Quaternary ammonium cation paired with benzoate anion; extremely bitter taste at ultra-low concentration, no toxic side effects under normal use; blocks taste bud receptors, widely used as aversion bitter additive
- Characteristic: World’s most bitter safe bitterant, standard anti-ingestion bitter additive for industrial products
Physical & Chemical Properties
- Appearance: White crystalline powder
- Odor: Odorless, intensely bitter taste even at ppm level
- Melting Point: 163–168 °C
- Solubility: Soluble in water, ethanol, methanol, propylene glycol; slightly soluble in acetone; insoluble in aliphatic hydrocarbons
- Stability: Stable under sealed dry storage; heat-resistant under conventional processing temperature; stable in neutral/weak acid/weak alkaline systems; compatible with most surfactants, resins, solvents
Synthesis & Applications
Production Method
Condensation of lidocaine, benzyl chloride to form denatonium chloride, then ion exchange with sodium benzoate, recrystallization purification.
Main Applications
- Industrial bitter deterrent: Add to antifreeze, paint, detergent, pesticide, solvent to prevent accidental swallowing by children/pets
- Cosmetic & personal care additive: Bitter agent for nail biting stop liquid, hair dye, industrial hand cleaner
- Pharmaceutical auxiliary: Bitter masking inhibitor for external liniment, veterinary oral repellent
- Daily chemical additive: Anti-chewing agent for plastic toys, plastic furniture, cables
Safety & Storage Instructions
GHS Hazard Classification
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H335 May cause respiratory irritation from dust inhalation
Personal Protection
Dust mask, chemical splash goggles, nitrile gloves; operate in ventilated workshop, avoid dust inhalation and eye contact.
Storage Condition
Hermetically sealed PE lined cardboard drum, cool dry warehouse ≤30℃; isolate oxidants, avoid high temperature.
Transportation
General low-toxic fine chemical powder; moisture-proof packaging, separated from food raw materials.
Quality Specifications
- Purity (HPLC): ≥99.0%
- Loss on Drying: ≤0.3%
- Residue on Ignition: ≤0.1%
- Heavy metal (Pb): ≤10 ppm
Information Summary Table
| Item | Specification |
| CAS Number | 3734-33-6 |
| Product Name | Denatonium benzoate |
| Synonym | Bitrex |
| Molecular Formula | C28H34N2O3 |
| Molecular Weight | 446.58 |
| Appearance | White crystalline powder |
| Melting Point | 163–168℃ |
| Core Advantage | Ultra-high bitterness safe bitterant, anti-ingestion additive for industrial & daily products |
| Storage Rule | Sealed dry storage, away from high temperature and oxidants |
| Hazard Property | Low acute toxicity, dust irritates skin, eyes and respiratory tract |
| Main Usage | Anti-swallow bitter additive for antifreeze/pesticide, nail biting inhibitor, cosmetic bitter agent, plastic anti-chewing auxiliary |
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