Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Information
- Full Name: Alpha-Methyl-L-Valine Hydrochloride
- Aliases: (S)-2-Amino-2,3-dimethylbutanoic acid hydrochloride, L-α-Methylvaline HCl
- CAS No.: 53940-83-3
- EINECS No.: N/A
- Molecular Formula: C6H14ClNO2
- Molecular Weight: 167.63
- Chemical Classification: Chiral amino acid hydrochloride, pharmaceutical intermediate, peptide synthesis raw material
- Core Product Features: High chiral purity, low racemization rate, stable crystalline form, excellent solubility in polar solvents, specially used for polypeptide drug synthesis, chiral catalyst research and biochemical reagent preparation, meets pharmaceutical intermediate impurity control standards
2. Detailed Physical & Chemical Properties
2.1 Physical Properties
- Appearance: White crystalline powder, uniform particle size, no caking, no visible foreign impurities
- Odor: Odorless
- Solubility: Freely soluble in water, methanol and ethanol; slightly soluble in isopropanol; insoluble in ethyl acetate, acetone and alkanes
- Specific Optical Rotation [α]D20: +10 ~ +14° (c=2, H2O)
- Melting Point: 242–246℃ (decompose upon melting)
- Boiling Point: Decompose above 250℃, no fixed boiling point under normal pressure
- Hygroscopicity: Slightly hygroscopic, needs sealed storage to avoid moisture absorption
2.2 Chemical Properties
- Chiral Stability: Single L-type chiral configuration, hardly racemize under normal temperature sealed storage
- Acid-base Characteristic: Amino acid hydrochloride, aqueous solution presents weak acidity; can react with alkali to generate free alpha-methyl-L-valine
- Thermal Stability: Stable below 200℃; high temperature will cause decomposition and destroy chiral structure
- Chemical Reactivity: Amino group and carboxyl group retain activity, can conduct amidation, esterification, peptide coupling reaction
- Compatibility: Compatible with most neutral and weak polar pharmaceutical solvents; incompatible with strong alkaline substances and strong oxidants
3. Comprehensive Product Applications
3.1 Pharmaceutical & Peptide Synthesis (Main Application)
Key chiral amino acid intermediate for synthetic polypeptide drugs, enzyme inhibitors and targeted small molecule medicines. It is used to construct special steric hindrance peptide fragments, improve metabolic stability of drugs, reduce enzymatic hydrolysis in human body, widely applied in anti-tumor, anti-viral and metabolic regulation drug R&D and production.
3.2 Biochemical Research & Laboratory Reagents
Standard chiral biochemical reagent for protein structure research, enzyme substrate research, chiral separation standard sample, used in university laboratories and pharmaceutical R&D institutions.
3.3 Chiral Catalysis & Fine Chemicals
Chiral building block for asymmetric synthesis, raw material for preparing chiral ligands and chiral resolution agents in fine chemical industry.
3.4 Other Fields
Raw material for cosmetic active peptide additives, plant growth regulator intermediate.
4. Full Parameter Specification Table
| Item | Detailed Standard Specification |
| CAS No. | 53940-83-3 |
| Molecular Formula | C6H14ClNO2 |
| Molecular Weight | 167.63 |
| Appearance | White crystalline powder |
| Melting Point | 242–246℃ (decompose) |
| Boiling Point | Decompose over 250℃, no fixed boiling point |
| Purity (HPLC) | ≥99.0% |
| Chiral Purity (ee) | ≥99.5% |
| Moisture Content | ≤0.5% |
| Heavy Metal (Pb) | ≤10 ppm |
| Bulk Packaging | 25kg aluminum foil lined fiber drum |
| Sample Packaging | 10g / 100g / 1kg sealed aluminum foil bag |
| Storage Condition | Sealed, light-proof, cool dry warehouse (≤25℃); away from strong alkali, oxidants and humid air |
| Transportation Standard | General pharmaceutical intermediate chemical, non-dangerous goods; waterproof, light-proof packaging during transit |
| Shelf Life | 24 months under original intact sealed packaging |
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