Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Information
- Full IUPAC Name: 4-[(5R)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]benzamide
- Common Name: Fluralaner
- Aliases: AH-252723, A-1443, Bravecto active ingredient
- CAS No.: 864731-61-3
- EINECS No.: 689-035-6
- Molecular Formula: C22H17Cl2F6N3O3
- Molecular Weight: 556.29
- Chemical Classification: Isoxazoline veterinary API, antiparasitic pharmaceutical raw material, chiral organic fine chemical
- Core Product Features
Chiral single R configuration, high insecticidal & acaricidal activity, long-lasting systemic efficacy, low mammalian toxicity, selective targeting on arthropod GABA chloride channel, low residual impurities, meets GMP veterinary API quality standards, stable crystal form for oral pet formulations
2. Detailed Physical & Chemical Properties
2.1 Physical Properties
- Appearance: White or off-white crystalline powder, uniform particle size, no caking
- Odor: Odorless
- Solubility: Soluble in DMSO, DMF, acetonitrile; slightly soluble in methanol, ethanol; insoluble in water, aliphatic alkanes
- Melting Point: 171–178℃
- Boiling Point: Decompose above 300℃, no fixed boiling point under normal pressure
- Optical Rotation: Specific rotation conforms to single R chiral specification
- Hygroscopicity: Slightly hygroscopic, must be stored under light-proof sealed environment
2.2 Chemical Properties
- Chiral Stability: Single R chiral isoxazoline structure, low racemization risk under normal temperature sealed storage
- Mechanism of Action: Selectively blocks glutamate-gated chloride channels (GluCl) and GABA-gated chloride channels of parasites, leading to nervous system overexcitation and death of fleas, ticks and mites
- Acid & Alkali Stability: Stable under neutral and weak acidic conditions; easily hydrolyzed under strong alkaline high-temperature environment
- Photostability: Easy to degrade under strong ultraviolet light, light-proof storage required
- Compatibility: Compatible with most veterinary formulation solvents and excipients; incompatible with strong oxidants and strong alkali substances
3. Comprehensive Product Applications
3.1 Veterinary Parasiticide API (Core Application)
Main active ingredient of oral long-acting pet anti-parasite medicine (trade name Bravecto). Used for systemic treatment and prevention of fleas, ticks, mites on dogs and cats, with up to 12 weeks lasting efficacy after single oral administration. Approved by FDA, EU EMA and global veterinary drug authorities.
3.2 Livestock & Poultry Pest Control
High-efficiency acaricide additive for poultry, pig and cattle breeding, controls red mites, lice and parasitic ticks to reduce breeding loss.
3.3 Biochemical Research & Laboratory Reagents
Standard reference substance for veterinary drug residue detection, ion channel research tool compound for insect neuroscience laboratory study.
3.4 Fine Chemical Intermediate
Chiral isoxazoline building block for synthesis of new antiparasitic and insecticidal candidate drugs in pharmaceutical R&D labs.
4. Full Parameter Specification Table
| Item | Detailed Standard Specification |
| CAS No. | 864731-61-3 |
| Molecular Formula | C22H17Cl2F6N3O3 |
| Molecular Weight | 556.29 |
| Appearance | White / off-white crystalline powder |
| Melting Point | 171–178℃ |
| Boiling Point | Decompose over 300℃, no fixed boiling point |
| HPLC Purity | ≥98.0% |
| Chiral Purity (ee) | ≥99.0% |
| Moisture Content (KF) | ≤0.5% |
| Total Impurities | ≤1.0% |
| Single Unknown Impurity | ≤0.20% |
| Residue on Ignition | ≤0.10% |
| Bulk Packaging | 25kg light-proof aluminum foil lined fiber drum |
| Sample Packaging | 1g / 10g / 100g sealed aluminum foil bag |
| Storage Condition | Sealed, light-proof, cool dry warehouse ≤25℃; away from strong light, oxidants, strong alkali and humid air |
| Transportation Standard | General pharmaceutical API chemical, non-dangerous goods; light-proof, waterproof packaging during transit |
| Shelf Life | 24 months under intact original sealed packaging |
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