Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Information
- Full Name: 5-Fluorouracil
- Abbreviation: 5-FU
- Aliases: 5-Fluoro-2,4(1H,3H)-pyrimidinedione
- CAS No.: 51-21-8
- EINECS No.: 200-085-6
- Molecular Formula: C4H3FN2O2
- Molecular Weight: 130.08
- Chemical Classification: Pyrimidine antimetabolite API, pharmaceutical intermediate, anti-tumor raw material
- Core Product Features
High purity crystalline powder, stable pyrimidine heterocyclic structure, specific anti-tumor activity by interfering nucleic acid synthesis. Strict impurity control complying with USP, EP, CP pharmacopoeia standards, widely used in injection, oral preparations and tumor research laboratories. Low moisture absorption, good thermal stability under sealed dark storage.
2. Detailed Physical & Chemical Properties
2.1 Physical Properties
- Appearance: White or off-white crystalline powder, uniform fine crystal, no caking, no visible foreign particles
- Odor: Odorless
- Solubility: Slightly soluble in water, soluble in dilute alkali solution; slightly soluble in methanol and ethanol; insoluble in chloroform, ether, benzene and aliphatic hydrocarbons
- pH Value (saturated aqueous solution): 4.5 ~ 5.5, weak acidity
- Melting Point: 282–286℃ (decompose while melting)
- Boiling Point: Decompose above 300℃, no fixed boiling point under normal pressure
- Hygroscopicity: Slightly hygroscopic, requires fully sealed storage to prevent moisture absorption
2.2 Chemical Properties
- Structural Characteristics: Fluorine substituted pyrimidine ring, structural analog of uracil, can replace uracil into tumor cell RNA and DNA to block cell proliferation
- Acid-base Stability: Stable in neutral and weak acid environment; dissolves and forms salt in strong alkaline aqueous solution; long-term strong alkaline heating will cause ring-opening degradation
- Photostability: Sensitive to ultraviolet light, easy to degrade and discolor under direct sunlight, must store away from light
- Thermal Stability: Stable below 250℃; melting temperature will produce thermal decomposition and release small molecule gas
- Chemical Reactivity: Active amide group on the ring, can carry out substitution, derivatization reaction to prepare 5-FU prodrug intermediates
- Safety Reminder: Cytotoxic raw material, avoid direct skin contact and inhalation of dust during operation
3. Comprehensive Product Applications
3.1 Pharmaceutical Anti-Tumor API (Core Application)
Classic anti-metabolite anti-tumor drug raw material. It inhibits tumor cell DNA replication and RNA transcription, clinically used for chemotherapy of colorectal cancer, gastric cancer, breast cancer, liver cancer, skin squamous cell carcinoma and other malignant tumors. Processed into injection, cream, oral sustained-release preparations by pharmaceutical factories.
3.2 Pharmaceutical Intermediate for Prodrug Synthesis
Raw material for synthesizing tegafur, capecitabine and other oral fluoropyrimidine anti-cancer prodrugs, used to improve oral bioavailability and reduce systemic side effects of 5-FU.
3.3 Biochemical & Laboratory Research Reagents
Standard reference substance for tumor pharmacology research, cell culture intervention reagent for oncology laboratories, tool compound for nucleic acid metabolism mechanism research.
3.4 Medical Cosmetic External Raw Material
Low-concentration external cream raw material for clinical treatment of viral skin lesions, warts and hyperplastic skin lesions under professional medical formula control.
4. Full Parameter Specification Table
| Item | Detailed Standard Specification |
| CAS No. | 51-21-8 |
| Molecular Formula | C4H3FN2O2 |
| Molecular Weight | 130.08 |
| Appearance | White or off-white crystalline powder |
| Melting Point | 282–286℃ (decompose) |
| Boiling Point | Decompose over 300℃, no fixed boiling point |
| HPLC Purity | ≥99.0% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Moisture Content (KF) | ≤0.30% |
| Heavy Metal (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Packaging | 25kg light-proof aluminum foil lined fiber drum |
| Sample Packaging | 5g / 100g / 1kg sealed light-proof aluminum foil bag |
| Storage Condition | Sealed, light-proof, cool dry warehouse below 25℃; strictly isolate strong alkali, oxidants and direct sunlight |
| Transportation Standard | Pharmaceutical cytotoxic raw material, separate from food, daily chemicals and strong corrosive goods during transit; light-proof and waterproof packaging |
| Shelf Life | 24 months under intact original sealed light-proof packaging |
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