Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Information
- Full Name: N,O-Bis(trimethylsilyl)acetamide
- Abbreviation: BSA
- Aliases: Acetamide N,O-bis(trimethylsilyl), N,O-Bis-TMS acetamide
- CAS No.: 10416-59-8
- EINECS No.: 233-892-7
- Molecular Formula: C8H21NOSi2
- Molecular Weight: 203.43
- Chemical Classification: Silylation derivatization reagent, organic silicon fine chemical, pharmaceutical synthesis intermediate, GC/HPLC derivatizing agent
- Core Product Features
High-efficiency neutral silylation reagent with mild reaction condition; fast derivatization of hydroxyl, carboxyl, amino groups; low by-product interference, widely used for gas chromatography sample pretreatment, chiral drug intermediate synthesis, carbohydrate and amino acid derivatization. Low moisture stability, high silylation activity, compatible with most anhydrous organic solvents.
2. Detailed Physical & Chemical Properties
2.1 Physical Properties
- Appearance: Colorless transparent low-viscosity liquid
- Odor: Slight characteristic silicon ether odor
- Solubility: Miscible with anhydrous dichloromethane, chloroform, acetonitrile, toluene, hexane; reacts violently with water, methanol and other protic solvents
- Density (20℃): 0.832 ~ 0.840 g/cm3
- Melting Point: -10℃
- Boiling Point: 71–73℃ (15 mmHg)
- Refractive Index nD20: 1.416 ~ 1.419
- Flash Point: 42℃
- Hygroscopicity: Extremely sensitive to water, hydrolyzes rapidly in humid air to generate hexamethyldisiloxane and acetamide
2.2 Chemical Properties
- Silylation Activity: Trimethylsilyl group rapidly replaces active hydrogen on -OH, -COOH, -NH2 to form stable volatile silyl derivatives for chromatographic detection
- Hydrolysis Characteristic: Decomposes immediately when exposed to water, must operate under anhydrous nitrogen protection
- Acid-Base Stability: Neutral reagent, no acid/base catalysis required for derivatization; stable under anhydrous neutral environment; decomposes in trace acid or alkaline water system
- Compatibility: Compatible with anhydrous aprotic solvents; strictly incompatible with water, alcohols, amines containing active hydrogen
- Thermal Stability: Stable below 80℃ under vacuum; high temperature above 120℃ causes slight decomposition
3. Comprehensive Product Applications
3.1 Chromatography Derivatization Reagent (Core Application)
Standard silylation reagent for GC/GC-MS analysis. Derivatize sugars, amino acids, steroids, organic acids, phenols to increase volatility, eliminate peak tailing, improve separation effect, widely used in food testing, pharmaceutical residue detection and biochemical laboratories.
3.2 Pharmaceutical Synthetic Intermediate
Protecting reagent for chiral drug synthesis, masks hydroxyl and amino groups during peptide, steroid and antibiotic synthesis to avoid side reactions; easy deprotection after synthesis.
3.3 Organic Silicon Fine Chemical Raw Material
Raw material for preparing other trimethylsilyl reagents, precursor for silicon-based blocking agents used in semiconductor wafer surface treatment.
3.4 Biochemical Research Auxiliary
Sample pretreatment reagent for natural product isolation, carbohydrate structure identification, cell metabolite detection in university research labs.
4. Full Parameter Specification Table
| Item | Detailed Standard Specification |
| CAS No. | 10416-59-8 |
| Molecular Formula | C8H21NOSi2 |
| Molecular Weight | 203.43 |
| Appearance | Colorless transparent liquid |
| Melting Point | -10℃ |
| Boiling Point | 71–73℃ (15 mmHg) |
| Purity (GC) | ≥98.0%; Chromatography Grade ≥99.0% |
| Moisture Content | ≤0.05% |
| Color (APHA) | ≤10 |
| Residue on Evaporation | ≤0.1% |
| Bulk Packaging | 200L lined steel drum / 25L plastic drum filled with nitrogen seal |
| Sample Packaging | 100ml / 500ml nitrogen-sealed glass bottle |
| Storage Condition | Hermetic nitrogen sealed warehouse, anhydrous environment below 25℃; strictly isolate water, humid air, alcohol and acid substances |
| Transportation Standard | Flammable organic liquid, separate from water-based chemicals, oxidants during transit; airtight packaging to prevent moisture ingress |
| Shelf Life | 12 months under intact nitrogen-sealed packaging |
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