Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Information
- Full Name: Alpha-Methyl-D-Valine
- Aliases: (R)-2-Amino-2,3-dimethylbutanoic acid, α-Methyl-D-valine
- CAS No.: 53940-82-2
- EINECS No.: N/A
- Molecular Formula: C6H13NO2
- Molecular Weight: 131.17
- Chemical Classification: Chiral unnatural amino acid, peptide synthesis building block, pharmaceutical intermediate
- Core Product Features
Single D chiral configuration, high enantiomeric purity, sterically hindered alpha-methyl substituted amino acid. Good solubility in polar protic solvents, low racemization risk during peptide coupling. Widely used for constructing steric hindrance peptide fragments, enzyme inhibitor drugs, targeted small molecule therapeutics and biochemical research standards.
2. Detailed Physical & Chemical Properties
2.1 Physical Properties
- Appearance: White crystalline powder, uniform fine crystal, no caking or foreign impurities
- Odor: Odorless
- Solubility: Freely soluble in water, methanol, ethanol; slightly soluble in isopropanol; insoluble in ethyl acetate, acetone, alkanes
- Specific Optical Rotation [α]D20: -10 ~ -14° (c=2, H?O)
- Melting Point: 240–245℃ (decompose on melting)
- Boiling Point: Decompose above 250℃, no fixed boiling point under normal pressure
- Hygroscopicity: Slightly hygroscopic, requires fully sealed storage to avoid moisture absorption
2.2 Chemical Properties
- Chiral Stability: Pure D single stereoisomer, no racemization under normal temperature sealed dark storage; high temperature or strong alkali will cause chiral inversion
- Amphoteric Characteristic: Contains free amino group and carboxyl group, forms internal salt in aqueous solution; can generate hydrochloride salt with inorganic acid
- Coupling Reactivity: Amino and carboxyl groups retain full activity, suitable for solid-phase peptide synthesis, amide condensation reactions
- Acid & Alkali Stability: Stable under neutral and weak acidic conditions; long-term heating in strong alkali solution leads to skeleton degradation
- Photostability: Stable under indoor ambient light; long-term intense UV exposure causes slow discoloration
3. Comprehensive Product Applications
3.1 Pharmaceutical Peptide Synthesis (Core Application)
Key chiral unnatural amino acid intermediate for anti-tumor, anti-viral and metabolic regulatory peptide drugs. The α-methyl group introduces steric hindrance to peptides, enhances metabolic stability and reduces enzymatic hydrolysis in vivo, improving drug half-life.
3.2 Biochemical Laboratory Research
Chiral standard reference material for amino acid chiral separation analysis; enzyme substrate research reagent for protease inhibition mechanism study; building block for synthetic peptide library screening.
3.3 Asymmetric Fine Chemical Synthesis
Chiral scaffold for asymmetric catalysis, raw material for manufacturing chiral ligands and chiral resolution agents in organic synthesis labs.
3.4 Cosmetic Active Peptide Intermediates
Raw material for synthetic anti-aging signal peptides used in high-end skincare formulations.
4. Full Parameter Specification Table
| Item | Detailed Standard Specification |
| CAS No. | 53940-82-2 |
| Molecular Formula | C6H13NO2 |
| Molecular Weight | 131.17 |
| Appearance | White crystalline powder |
| Melting Point | 240–245℃ (decompose) |
| Boiling Point | Decompose over 250℃, no fixed boiling point |
| HPLC Chemical Purity | ≥99.0% |
| Chiral Purity (ee) | ≥99.5% |
| Moisture Content (KF) | ≤0.5% |
| Heavy Metal (Pb) | ≤10 ppm |
| Bulk Packaging | 25kg aluminum foil lined fiber drum |
| Sample Packaging | 10g / 100g / 1kg sealed light-proof aluminum foil bag |
| Storage Condition | Sealed, light-proof, cool dry warehouse ≤25℃; isolate humid air, strong alkali and oxidants |
| Transportation Standard | General pharmaceutical intermediate chemical, non-dangerous goods; waterproof and light-proof packaging required during transit |
| Shelf Life | 24 months under intact original sealed packaging |
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