Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 4-Amino-3-phenylbutanoic acid
- Aliases: 3-Phenyl-4-aminobutyric acid
- CAS Number: 1078-21-3
- EINECS: N/A
- Molecular Formula: C10H13NO2
- Molecular Weight: 179.22
- Chemical Classification: Aromatic aliphatic amino acid, pharmaceutical intermediate, GABA derivative research reagent
- Core Advantages
Amino acid derivative with phenyl substituent, contains free amino and carboxyl groups, easy to conduct amidation, esterification, acylation condensation reactions. Key scaffold for central nervous system modulator drugs, widely used in pharmaceutical synthetic labs and neuropharmacology research.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Soluble in water, methanol, ethanol; slightly soluble in ethyl acetate; insoluble in n-hexane, benzene
- Melting Point: 208–212°C (decomposition)
- Hygroscopy: Slightly hygroscopic, need sealed storage
- pH of aqueous suspension: Weakly acidic
2.2 Chemical Properties
- Amphoteric property: Contains -NH2 and -COOH, can form salts with inorganic acids and alkalis
- Condensation reactivity: Amino group undergoes acylation, Boc/Fmoc protection for peptide synthesis; carboxyl group can form ester and amide derivatives
- Thermal stability: Stable below 180°C; decomposes over melting point to release small molecule gas
- Light stability: Stable under normal indoor light; long-term strong UV irradiation causes slight discoloration
- Compatibility: Stable in neutral and weak acid system; incompatible with strong oxidants and concentrated strong alkali
3. Main Application Fields
3.1 Pharmaceutical Synthetic Intermediate (Core Usage)
Precursor for synthetic GABA receptor regulators, anti-anxiety, anti-epileptic and neuroprotective small molecule drugs. The phenyl modified butanoic acid skeleton improves blood-brain barrier permeability of target molecules.
3.2 Biochemical Research Reagent
Tool compound for gamma-aminobutyric acid (GABA) receptor mechanism research, standard substrate for amino acid metabolic pathway experiments in university pharmacology labs.
3.3 Peptide Synthesis Building Block
Unnatural aromatic amino acid fragment for constructing bioactive peptide libraries, used in high-throughput drug screening.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 1078-21-3 |
| Molecular Formula | C10H13NO2 |
| Molecular Weight | 179.22 |
| Appearance | White to off-white crystalline powder |
| Melting Range | 208–212°C (decompose) |
| HPLC Purity | ≥99.0% |
| Single maximum unknown impurity | ≤0.10% |
| Total related substances | ≤0.50% |
| Moisture Content (KF) | ≤0.40% |
| Heavy Metals (Pb) | ≤10 ppm |
| Bulk Package | 25kg aluminum foil lined fiber drum |
| Sample Package | 10g / 100g / 1kg sealed aluminum foil bag |
| Storage Requirements | Sealed, cool dry warehouse below 25℃; avoid strong light, humid air and oxidants |
| Transportation Rule | General organic fine chemical, non-dangerous goods, waterproof packaging required |
| Shelf Life | 24 months under intact sealed packaging |
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