Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: (5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide
- Aliases: GI 198745, Avodart API, Dutasteride Raw Material
- CAS Number: 164656-23-9
- EINECS: N/A
- Molecular Formula: C27H30F6N2O2
- Molecular Weight: 528.53
- Chemical Classification: Fluorinated azasteroid API, dual 5α-reductase inhibitor, androgen regulatory pharmaceutical raw material
- Core Advantages
Synthetic fluorine-containing 4-azasteroid compound, dual potent inhibitor of 5α-reductase Type 1 & Type 2, far stronger DHT suppression effect than finasteride. Complies with USP/EP pharmacopoeia standards, strict control of related substances and residual solvents; long half-life in vivo, widely used for benign prostatic hyperplasia treatment and androgen-related hair loss drug synthesis.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White to pale yellow crystalline powder
- Odor: Odorless
- Solubility: Soluble in methanol, ethanol, dichloromethane, chloroform, PEG400; practically insoluble in pure water
- Melting Point: 244–248°C
- Hygroscopy: Non-hygroscopic, stable under normal dry storage
- Lipophilicity: High fat solubility, suitable for soft capsule oil formulation
- Skin Permeability: Can be absorbed through skin; pregnant women are prohibited from direct contact
2.2 Chemical Properties
- Steroid Heterocyclic Structure: Contains 4-aza steroid skeleton + bis(trifluoromethyl)phenyl amide side chain; trifluoromethyl groups improve metabolic stability and target binding affinity
- Pharmacological Mechanism: Blocks testosterone conversion to dihydrotestosterone (DHT), reduces prostate tissue stimulation by androgen
- Acid & Alkali Stability: Stable under neutral and weak acidic conditions; amide group hydrolyzes under strong alkaline heating
- Photostability: Slightly sensitive to strong UV light; long-term light exposure causes slow yellow discoloration
- Thermal Stability: Stable below 200°C; obvious thermal decomposition occurs above melting temperature
- Compatibility: Compatible with medium-chain triglycerides, vitamin E and pharmaceutical oily excipients; incompatible with strong oxidants
3. Main Application Fields
3.1 Pharmaceutical API (Core Usage)
Active raw material for oral soft capsule drugs for benign prostatic hyperplasia (BPH). Significantly reduces prostate volume, improves lower urinary tract obstruction symptoms, lowers risk of acute urinary retention and prostate surgery; also used for clinical androgenetic alopecia treatment auxiliary formulations.
3.2 Pharmaceutical Synthetic Intermediate
Key fluorinated steroid building block for developing new selective 5α-reductase inhibitor derivatives, used in pharmaceutical R&D pilot synthesis lines.
3.3 Biomedical Research Reagent
Standard reference substance for androgen metabolism research, tool compound for prostate cell pharmacology screening in university pharmaceutical laboratories.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 164656-23-9 |
| Molecular Formula | C27H30F6N2O2 |
| Molecular Weight | 528.53 |
| Appearance | White to pale yellow crystalline powder |
| Melting Range | 244–248°C |
| HPLC Chemical Purity | Pharma Grade ≥99.5% |
| Single Maximum Unknown Impurity | ≤0.05% |
| Total Related Substances | ≤0.30% |
| Moisture Content (KF) | ≤0.20% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residual Solvents | Meet EP/USP limits |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof aluminum foil lined fiber drum |
| Sample Package | 1g / 10g / 100g sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof warehouse below 30℃; isolate strong light, oxidants and alkaline substances; strictly avoid contact by pregnant women |
| Transportation Rule | Steroid pharmaceutical API, non-dangerous goods; light-proof and waterproof packaging mandatory during transit |
| Shelf Life | 48 months under intact original light-proof sealed packaging |
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