Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 2-(2-Chloroethoxy)ethanol
- Aliases: Chloroethoxy ethanol, 2-Chloro-2'-hydroxydiethyl ether
- CAS Number: 628-89-7
- EINECS: 211-056-3
- Molecular Formula: C4H9ClO2
- Molecular Weight: 124.56
- Chemical Classification: Chlorinated ether alcohol fine chemical, pharmaceutical intermediate, organic synthesis alkylating agent
- Core Advantages
Contains hydroxyl and chloroalkyl dual functional groups, moderate reactivity, stable under anhydrous neutral conditions. Widely used for constructing heterocyclic drug skeletons, surfactant synthesis, pesticide intermediate preparation and organic derivatization reactions.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: Colorless transparent viscous liquid
- Odor: Mild ether characteristic odor
- Solubility: Miscible with water, ethanol, methanol, dichloromethane, toluene; insoluble in aliphatic alkanes
- Density (20℃): 1.180 ~ 1.190 g/cm3
- Boiling Point: 80–83 °C (12 mmHg)
- Refractive Index nD20: 1.452 ~ 1.456
- Hygroscopy: Slightly hygroscopic; chlorine group prone to slow hydrolysis in long-term contact with water
2.2 Chemical Properties
- Dual Functional Group Reactivity
- Terminal -OH: Esterification, etherification, silylation, acylation reactions
- Terminal -Cl: Nucleophilic substitution with amines, alcohols, thiols to extend carbon chain
- Hydrolysis Characteristic
Slowly hydrolyzes in hot water/alkaline aqueous solution to generate diethylene glycol and chloride salt; stable under cold neutral anhydrous environment - Thermal Stability
Stable below 100°C under normal pressure; high temperature above 180°C triggers dehydrochlorination to form vinyl ether byproducts - Acid & Alkali Compatibility
Stable in weak acid/neutral medium; concentrated strong alkali accelerates dehydrochlorination; reacts violently with strong oxidants - Corrosivity: Mild irritant to skin, eyes and respiratory tract
3. Main Application Fields
3.1 Pharmaceutical Synthetic Intermediate (Core Usage)
Alkylation building block for antihistamine, cardiovascular, anti-inflammatory small molecule drugs; used to introduce hydrophilic ether side chains to improve drug water solubility.
3.2 Pesticide & Biocide Intermediates
Precursor for synthesis of insecticides, fungicides and plant growth regulators; chloroalkyl group provides binding site for target biological molecules.
3.3 Surfactant & Polymer Auxiliaries
Raw material for synthesizing nonionic surfactants, polyether modified monomers; hydroxyl group participates in polycondensation for water-soluble resin production.
3.4 Organic Chemistry Laboratory Reagent
Nucleophilic alkylation reagent for custom fine chemical synthesis, used to prepare functional ether derivatives.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 628-89-7 |
| Molecular Formula | C4H9ClO2 |
| Molecular Weight | 124.56 |
| Appearance | Colorless transparent liquid |
| Purity (GC) | Industrial Grade ≥98.0%; Synthesis Grade ≥99.0% |
| Water Content (KF) | ≤0.20% |
| Free Chloride Ion | ≤0.05% |
| Color (APHA) | ≤30 |
| Bulk Package | 200L lined steel drum |
| Sample Package | 1L / 5L sealed plastic bottle |
| Storage Requirements | Hermetic cool dry warehouse ≤25℃; isolate water, alkaline substances and strong oxidants |
| Transportation Rule | Hazardous organic chlorinated liquid; follow corrosive organic liquid transport standards, separate from alkalis and oxidants |
| Shelf Life | 12 months under intact sealed packaging |
...
Product
