Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 2-(Diphenylmethoxy)-N,N-dimethylethanamine hydrochloride
- Aliases: Benadryl HCl, Diphenhydramine HCl
- CAS Number: 147-24-0
- EINECS: 205-687-2
- Molecular Formula: C17H22ClNO
- Molecular Weight: 291.82
- Chemical Classification: Antihistamine API, pharmaceutical raw material, anti-allergy intermediate
- Core Advantages
First-generation H1 histamine receptor antagonist, stable hydrochloride salt form, good water solubility. Used for relieving allergic rhinitis, urticaria, motion sickness and insomnia; widely applied in oral tablets, injection solutions, topical ointment formulations, compliant with USP/EP pharmacopoeia standards.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White crystalline powder
- Odor: Odorless, bitter taste
- Solubility: Freely soluble in water, methanol, ethanol; slightly soluble in acetone; insoluble in ether, benzene
- Melting Point: 167–172 °C
- pH (10% aqueous solution): 4.0 ~ 6.0, weak acidic
- Hygroscopy: Slightly hygroscopic under high humidity
- Optical property: Non-chiral compound, no optical rotation
2.2 Chemical Properties
- Salt structure: Amine hydrochloride salt, dissociates into diphenhydramine cation and chloride ion in aqueous solution
- Acid-base reaction: Aqueous solution reacts with strong alkali to precipitate free diphenhydramine base oil
- Thermal stability: Stable below 120°C; prolonged heating above melting point causes decomposition
- Photostability: Avoid long-term strong UV irradiation to prevent yellow discoloration
- Compatibility: Compatible with common pharmaceutical excipients; incompatible with strong oxidants and alkaline additives
3. Main Application Fields
3.1 Pharmaceutical API (Core Usage)
Raw material for anti-allergy medicines: anti-itch tablets, cold relief compound preparations, motion sickness drugs, sleep aid oral formulations; also used in injectable liquid for clinical anti-anaphylaxis adjuvant treatment.
3.2 Topical Ointment Raw Material
Functional additive for anti-itch skin cream, insect bite relief lotion, inhibits allergic skin inflammatory reaction.
3.3 Chemical Laboratory Reference Standard
Control standard for HPLC drug impurity analysis, pharmaceutical quality testing reagent.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 147-24-0 |
| Molecular Formula | C17H22ClNO |
| Molecular Weight | 291.82 |
| Appearance | White crystalline powder |
| Melting Range | 167–172 °C |
| HPLC Assay | Pharma Grade ≥99.0% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Moisture Content (KF) | ≤0.30% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof aluminum foil lined fiber drum |
| Sample Package | 10g / 100g / 1kg sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof cool dry warehouse ≤25℃; separate from alkaline chemicals and oxidants |
| Transportation Rule | General pharmaceutical API, non-hazardous goods; light-proof waterproof packaging required |
| Shelf Life | 36 months under intact original sealed packaging |
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