Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 2-morpholin-4-ylethyl 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate
- Aliases: Morniflumate, UP 164, Niflumic acid β-morpholinoethyl ester
- CAS Number: 65847-85-0
- EINECS: N/A
- Molecular Formula: C19H20F3N3O3
- Molecular Weight: 395.38
- Chemical Classification: NSAID API, fluorinated pyridine pharmaceutical raw material, anti-inflammatory bulk active ingredient
- Core Advantages
Oral prodrug non-steroidal anti-inflammatory agent of fenamate series. Rapidly hydrolyzed in vivo to niflumic acid to generate COX inhibitory activity, delivering anti-inflammatory, analgesic and antipyretic effects. High purity meets pharmaceutical research standards, applied in drug development for osteoarthritis, soft tissue inflammation and musculoskeletal pain; available as GMP bulk API and lab reference standard grades.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White to pale light yellow crystalline powder
- Odor: Odorless
- Solubility: Slightly soluble in methanol, DMSO; practically insoluble in water, aliphatic alkanes
- Melting Point: 75–77 °C
- Predicted Density: 1.312 g/cm3
- Storage Condition: Hermetic light-proof storage at 2–8°C
- Hygroscopy: Slightly hygroscopic under high humidity
2.2 Chemical Properties
- Ester Prodrug Structure: Morpholine ethyl ester derivative of niflumic acid; ester bond hydrolyzes in gastrointestinal tract and blood to release active niflumic acid
- Fluorinated Aromatic Skeleton: Trifluoromethyl phenyl group improves metabolic stability and target binding affinity
- Acid & Alkali Stability: Stable under neutral and weak acid environments; ester hydrolysis occurs under heating with strong alkaline solution
- Photostability: Sensitive to intense UV light; long-term light exposure triggers yellow discoloration
- Compatibility: Compatible with neutral pharmaceutical excipients; incompatible with strong oxidants and concentrated alkali
3. Main Application Fields
3.1 Pharmaceutical API (Core Usage)
Active raw material for oral anti-inflammatory analgesic preparations, clinically indicated for osteoarthritis, rheumatoid inflammation, soft tissue contusion pain and adjuvant anti-inflammatory treatment of bronchitis.
3.2 Pharmacological Research Reagent
Tool compound for COX-1/COX-2 inhibition mechanism research; standard reference substance for HPLC drug impurity detection in pharmaceutical R&D institutes and university pharmacology labs.
3.3 Synthetic Building Block for Novel Drug Derivatives
Fluorinated pyridine scaffold for developing new selective non-steroidal anti-inflammatory candidates, used in compound library construction and high-throughput drug screening.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 65847-85-0 |
| Molecular Formula | C19H20F3N3O3 |
| Molecular Weight | 395.38 |
| Appearance | White to pale yellow crystalline powder |
| Melting Range | 75–77 °C |
| HPLC Assay | Pharma Grade ≥99.0%; Research Grade ≥99.5% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Moisture (KF) | ≤0.30% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof fiber drum lined with nitrogen-sealed aluminum foil |
| Sample Package | 1g / 10g / 100g sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic light-proof refrigerated warehouse (2–8°C); isolate humid air, intense light, oxidants and alkaline substances |
| Transportation Rule | Non-hazardous pharmaceutical anti-inflammatory API; light-proof, waterproof and low-temperature packaging is mandatory during transit |
| Shelf Life | 36 months under intact original nitrogen-sealed light-proof packaging |
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