Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: N-benzoyl-D-2-phenylglycine
- Aliases: N-Benzoyl-D-α-phenylglycine
- CAS Number: 10419-67-7
- EINECS: N/A
- Molecular Formula: C15H13NO3
- Molecular Weight: 255.27
- Chemical Classification: Chiral amino acid derivative, pharmaceutical chiral resolution agent, peptide synthesis building block
- Core Advantages
Pure D single chiral configuration, benzoyl protected phenylglycine structure. Excellent chiral resolution performance for separating racemic amine, alcohol and pharmaceutical chiral intermediates; stable stereochemistry without racemization under conventional storage, widely used in chiral drug splitting and peptide fragment synthesis.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White crystalline powder
- Odor: Odorless
- Solubility: Soluble in methanol, ethanol, acetone, DMSO; slightly soluble in ethyl acetate; insoluble in water, aliphatic alkanes
- Melting Point: 184–188 °C
- Specific Optical Rotation [α]D20: -145° ~ -155° (c=1, ethanol)
- Hygroscopy: Non-hygroscopic under normal dry environment
- Crystal Feature: Uniform fine crystal with good filtration performance
2.2 Chemical Properties
- Amphoteric Functional Groups: Contains free carboxyl group and benzoyl protected amino group, capable of salt formation with organic amines for chiral resolution
- Chiral Resolution Mechanism: Forms diastereomeric salts with racemic chiral compounds, realizing separation via recrystallization
- Deprotection Reaction: Benzoyl group removable under strong acid hydrolysis to obtain free D-phenylglycine
- Acid & Alkali Stability: Stable under neutral and weak acidic conditions; prolonged heating with strong alkali triggers partial racemization
- Photostability: Stable under indoor light; long-term intense UV exposure causes slight yellowing
- Compatibility: Compatible with most polar organic solvents; incompatible with concentrated strong alkali and strong oxidants
3. Main Application Fields
3.1 Chiral Resolution Agent (Core Usage)
Industrial splitting reagent for racemic aromatic amines, β-lactam antibiotic intermediates and cardiovascular chiral drug fragments; widely applied in chiral separation production lines of pharmaceutical factories.
3.2 Chiral Synthetic Building Block
Protected D-phenylglycine fragment for peptide synthesis, raw material for constructing chiral compound libraries in new drug screening laboratories.
3.3 Analytical Reference Standard
Chiral HPLC calibration standard for optical purity testing of amino acid derivatives in pharmaceutical quality control labs.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 10419-67-7 |
| Molecular Formula | C15H13NO3 |
| Molecular Weight | 255.27 |
| Appearance | White crystalline powder |
| Melting Range | 184–188 °C |
| HPLC Chemical Purity | ≥99.0% |
| Enantiomeric Excess (ee) | ≥99.5% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Moisture Content (KF) | ≤0.30% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof aluminum foil lined nitrogen-sealed fiber drum |
| Sample Package | 10g / 100g / 1kg sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof cool dry warehouse ≤25℃; isolate humid air, strong light, oxidants and concentrated alkaline substances |
| Transportation Rule | General chiral pharmaceutical intermediate, non-hazardous goods; light-proof waterproof packaging mandatory during transit |
| Shelf Life | 24 months under intact nitrogen-sealed light-proof packaging |
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