Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 2-methyl-2-[(E)-benzylideneamino]propan-1-ol
- Aliases: (E)-N-(2-hydroxy-2-methylpropyl)benzaldimine, Benzaldehyde 2-hydroxy-2-methylpropyl imine
- CAS Number: 22563-90-2
- EINECS: N/A
- Molecular Formula: C11H15NO
- Molecular Weight: 177.24
- Chemical Classification: Aromatic imine chiral synthetic intermediate, bifunctional hydroxyl imine building block
- Core Advantages
Contains E-configured C=N imine bond and primary hydroxyl group, dual reactive functional groups for derivatization. Serves as key precursor for asymmetric amine synthesis, chiral ligand preparation and pharmaceutical heterocyclic scaffold construction; stable E-isomer form with minimal isomerization under standard anhydrous storage.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: Pale yellow transparent oily liquid
- Odor: Mild aromatic imine odor
- Solubility: Soluble in methanol, ethanol, DCM, toluene, THF; slightly soluble in hexane; insoluble in water
- Boiling Point: Distills under reduced pressure
- Refractive Index nD20: 1.520–1.528
- Hygroscopy: Slightly hygroscopic, prone to hydrolysis in humid air
- Stereo Property: Exclusive E geometric isomer, no Z-isomer impurity in qualified grade
2.2 Chemical Properties
- Dual Functional Group Reactivity
- Imine (C=N): Nucleophilic addition, reduction to secondary amine, cycloaddition for heterocycle synthesis
- Terminal -OH: Esterification, silylation, etherification to introduce protecting groups
- Hydrolysis Characteristic: Rapidly hydrolyzes under aqueous acidic environment to benzaldehyde and 2-amino-2-methylpropan-1-ol; stable under anhydrous neutral/weak alkaline conditions
- Thermal Stability: Stable below 110°C; high temperature above 160°C triggers imine isomerization and decomposition
- Photostability: Avoid long-term intense UV irradiation to prevent discoloration and E/Z isomer conversion
- Compatibility: Compatible with anhydrous organic solvents; incompatible with water, mineral acids and strong oxidants
3. Main Application Fields
3.1 Chiral Synthetic Intermediate (Core Usage)
Precursor for asymmetric reduction to prepare chiral β-amino alcohol ligands and pharmaceutical amine intermediates; used for constructing nitrogen-containing heterocyclic core skeletons in small-molecule drug development.
3.2 Organic Catalysis Research Reagent
Imine substrate for asymmetric catalytic hydrogenation, Lewis acid coordination reaction experiments in university synthetic chemistry labs.
3.3 Fine Chemical Derivatization Building Block
Raw material for synthesizing corrosion inhibitors, chelating agents and specialty amine surfactants.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 22563-90-2 |
| Molecular Formula | C11H15NO |
| Molecular Weight | 177.24 |
| Appearance | Pale yellow oily liquid |
| GC Purity | Synthesis Grade ≥98.0%; Research Grade ≥99.0% |
| E-Isomer Content | ≥99.0% |
| Water Content (KF) | ≤0.15% |
| Free Benzaldehyde | ≤0.20% |
| Color (APHA) | ≤120 |
| Bulk Package | 200L lined plastic drum with nitrogen seal |
| Sample Package | 1L / 5L sealed nitrogen-filled plastic bottle |
| Storage Requirements | Hermetic nitrogen-sealed cool dry warehouse ≤25℃; isolate humid air, acidic substances and strong light |
| Transportation Rule | General organic synthetic intermediate, non-hazardous goods; airtight waterproof packaging required during transit |
| Shelf Life | 12 months under intact nitrogen-sealed packaging |
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