Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
- Aliases: Colchicine
- CAS Number: 64-86-8
- EINECS: 200-598-5
- Molecular Formula: C22H25NO6
- Molecular Weight: 399.44
- Chemical Classification: Natural plant alkaloid API, tubulin inhibitor pharmaceutical active ingredient
- Core Advantages
Natural tropolone alkaloid extracted from Colchicum autumnale. Strong tubulin polymerization inhibitory activity, blocks mitosis and inflammatory cell migration. Clinically approved for acute gout flare treatment, pericarditis and anti-fibrosis research. High purity meets USP/EP pharmacopoeia standards, applied in oral tablet formulations and cell biology laboratory research.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: Pale yellow crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in ethanol, chloroform, DMSO; slightly soluble in water; insoluble in aliphatic alkanes
- Melting Point: 142–150 °C
- Specific Optical Rotation [α]D20: -121° ~ -132° (c=1, chloroform)
- Hygroscopy: Non-hygroscopic under dry storage conditions
- Optical Property: Exhibits characteristic UV absorption under ultraviolet light
2.2 Chemical Properties
- Polycyclic Alkaloid Skeleton: Contains multiple methoxy groups and acetylamide functional group that determine biological activity
- Acid & Alkali Stability: Stable under neutral and weak acidic environments; amide hydrolysis occurs under heating with strong alkaline solution
- Thermal Stability: Slow decomposition under long-term heating above 160 °C
- Photostability: Highly sensitive to UV irradiation; prolonged light exposure causes color darkening and impurity generation
- Compatibility: Compatible with neutral pharmaceutical excipients; incompatible with strong oxidants, concentrated alkalis and heavy metal salts
3. Main Application Fields
3.1 Pharmaceutical API (Core Usage)
Active raw material for oral anti-gout tablets, clinically used to relieve acute gout inflammation and pain; also utilized for recurrent pericarditis treatment preparations.
3.2 Cell Biology Research Reagent
Standard mitotic inhibitor for cell cycle blocking experiments, tubulin binding research in academic biochemistry laboratories.
3.3 Anti-Fibrosis Drug Development Building Block
Lead compound for developing novel anti-inflammatory and anti-fibrosis small-molecule therapeutic candidates.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 64-86-8 |
| Molecular Formula | C22H25NO6 |
| Molecular Weight | 399.44 |
| Appearance | Pale yellow crystalline powder |
| Melting Range | 142–150 °C |
| HPLC Assay | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Moisture Content (KF) | ≤0.30% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof nitrogen-sealed aluminum foil lined fiber drum |
| Sample Package | 1g / 10g / 100g sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic light-proof cool dry warehouse ≤25℃; fully isolate intense light, humid air and alkaline substances |
| Transportation Rule | Toxic alkaloid API; light-proof sealed packaging with hazard label mandatory during transit |
| Shelf Life | 36 months under intact nitrogen-sealed light-proof packaging |
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