Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 2-(Cyclohexylcarbonyl)-1,2,3,4,6,7-hexahydropyrazino[2,1-a]isoquinolin-4-one
- Aliases: Praziquantel, PZQ
- CAS Number: 55268-74-1
- EINECS: 259-559-6
- Molecular Formula: C19H24N2O2
- Molecular Weight: 312.41
- Chemical Classification: Broad-spectrum antiparasitic API, heterocyclic anthelmintic bulk drug
- Core Advantages
High-efficiency broad-spectrum trematode and cestode inhibitor. Disturbs parasite calcium ion balance to induce muscle paralysis and death. Clinically used for human schistosomiasis, tapeworm infection and livestock deworming. High purity meets USP/EP veterinary and human pharmaceutical standards, applied in oral tablet and suspension formulation production.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Soluble in ethanol, chloroform, DMSO; slightly soluble in methanol; practically insoluble in water
- Melting Point: 136–140 °C
- Hygroscopy: Non-hygroscopic under dry storage environment
- Crystal Feature: Fine uniform crystals with good mixing performance for solid formulations
2.2 Chemical Properties
- Fused Pyrazinoisoquinoline Skeleton: Cyclohexyl ketone group dominates antiparasitic biological activity
- Acid & Alkali Stability: Stable under neutral, weak acid and weak alkaline conditions; no obvious hydrolysis at room temperature
- Thermal Stability: Slow decomposition occurs when heated continuously above 160 °C
- Photostability: Slightly sensitive to strong UV light; long-term light exposure causes faint yellow discoloration
- Compatibility: Compatible with common solid pharmaceutical excipients; incompatible with strong oxidants and hot concentrated mineral acids
3. Main Application Fields
3.1 Human Pharmaceutical API (Core Usage)
Raw material for oral anti-schistosome and anti-tapeworm tablets, indicated for schistosomiasis, cysticercosis and intestinal tapeworm infections in human clinical treatment.
3.2 Veterinary Drug Raw Material
Core active ingredient for livestock, poultry and aquatic animal deworming preparations against flukes and tapeworms.
3.3 Pharmacological Research Reference Standard
Control compound for in vitro parasite activity screening and HPLC impurity detection in pharmaceutical labs.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 55268-74-1 |
| Molecular Formula | C19H24N2O2 |
| Molecular Weight | 312.41 |
| Appearance | White to off-white crystalline powder |
| Melting Range | 136–140 °C |
| HPLC Assay | Pharma Grade ≥99.0%; Veterinary Grade ≥98.5% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Moisture Content (KF) | ≤0.30% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof fiber drum lined with nitrogen-sealed aluminum foil |
| Sample Package | 10g / 100g / 1kg sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof cool dry warehouse ≤25℃; isolate humid air, intense light and oxidants |
| Transportation Rule | Non-hazardous antiparasitic API; light-proof waterproof packaging mandatory during transit |
| Shelf Life | 36 months under intact nitrogen-sealed light-proof packaging |
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