Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: Di(1H-imidazol-1-yl)methanone
- Aliases: CDI, Carbonyldiimidazole
- CAS Number: 530-62-1
- EINECS: 208-488-9
- Molecular Formula: C7H6N4O
- Molecular Weight: 162.15
- Chemical Classification: Carbonylation coupling reagent, peptide & pharmaceutical synthetic intermediate, dehydration activator
- Core Advantages
High-efficiency non-chloride acylating activator. Activates carboxylic acids into reactive imidazolide intermediates under mild anhydrous conditions, widely used for esterification, amidation, peptide coupling, carbamate & urea synthesis. Byproduct imidazole is easily removed, no toxic halogen residues; suitable for complex API, chiral drug and biochemistry synthesis.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White crystalline powder
- Odor: Slight imidazole characteristic odor
- Solubility: Soluble in anhydrous THF, DCM, DMF, chloroform; reacts rapidly with water & alcohols
- Melting Point: 116–122 °C
- Hygroscopy: Extremely hygroscopic, instantly hydrolyzes when exposed to moisture
- Crystal Feature: Uniform fine crystals for fast reaction dissolution
2.2 Chemical Properties
- Active carbonyl bridge structure: Reacts with H2O to generate CO2 + imidazole; reacts with ROH to form carbonate; reacts with RNH2 to form amide/urea
- Activation mechanism: Converts -COOH to acylimidazole, mild reaction without high temperature
- Acid & Alkali Stability: Stable under strict anhydrous neutral environment; instantly decomposed by water, dilute acid, protic solvents
- Thermal Stability: Slow decomposition above 130°C, releases CO2
- Photostability: Light stable under sealed anhydrous condition
- Compatibility: Compatible with anhydrous aprotic solvents; strictly incompatible with water, methanol, ethanol, amines without protection
3. Main Application Fields
3.1 Pharmaceutical API Synthesis (Core Usage)
Key coupling reagent for peptide drugs, chiral intermediates, antibiotics and small-molecule anticancer APIs; replaces toxic phosgene and DCC for amide/carbamate formation.
3.2 Biochemical Research Reagent
Activator for protein modification, amino acid derivatization, oligonucleotide synthesis in biochemistry labs.
3.3 Fine Chemical & Polymer Intermediate
Synthesis of polyurea, polycarbamate, crosslinking agents for coating and adhesive systems.
3.4 Analytical Chemistry Derivatization Agent
Derivatization reagent for chromatographic detection of carboxylic acid compounds.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 530-62-1 |
| Molecular Formula | C7H6N4O |
| Molecular Weight | 162.15 |
| Appearance | White crystalline powder |
| Melting Range | 116–122 °C |
| HPLC Assay | Synthesis Grade ≥98.0%; Pharma Grade ≥99.0% |
| Free Imidazole | ≤0.30% |
| Moisture Content (KF) | ≤100 ppm |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg nitrogen-sealed aluminum foil lined fiber drum |
| Sample Package | 10g / 100g / 1kg argon-filled sealed aluminum foil bag |
| Storage Requirements | Hermetic inert gas sealed low-humidity warehouse ≤25℃; fully isolate air, moisture, protic solvents |
| Transportation Rule | Moisture-sensitive coupling reagent; nitrogen-filled fully sealed packaging mandatory during transit |
| Shelf Life | 24 months under intact argon-sealed packaging |
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