Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 1-bromopyrrolidine-2,5-dione
- Aliases: NBS, N-Bromosuccinimide
- CAS Number: 128-08-5
- EINECS: 204-876-6
- Molecular Formula: C4H4BrNO2
- Molecular Weight: 177.98
- Chemical Classification: Organic brominating reagent, mild oxidant, synthetic pharmaceutical intermediate
- Core Advantages
Mild selective bromination reagent with stable solid form. Realizes allylic/benzylic bromination, electrophilic aromatic bromination and alcohol oxidation under neutral mild conditions. Low corrosivity, easy post-treatment, widely used in API synthesis, conjugated material preparation and organic chemistry lab research.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White to off-white crystalline powder
- Odor: Slight bromine irritating odor
- Solubility: Slightly soluble in water; soluble in THF, DMF, DMSO, hot chloroform; insoluble in cold aliphatic alkanes
- Melting Point: 172–176 °C (decomposition)
- Hygroscopy: Slightly hygroscopic, decomposes slowly in humid air releasing Br2
- Crystal Character: Uniform fine crystal with good dispersion in anhydrous organic solvents
2.2 Chemical Properties
- N-Bromo active functional group: Slow homolytic cleavage under light/heat to generate bromine free radical for selective alkyl bromination
- Selective reactivity: Preferentially brominate allylic, benzylic C-H without attacking aromatic ring under radical condition
- Acid & Alkali Stability: Stable in dry neutral environment; hydrolyzes in water to succinimide + hypobromous acid; reacts violently with strong alkali
- Thermal Stability: Gradually decomposes above 160 °C, releases bromine vapor
- Photostability: Highly sensitive to UV/strong light; light exposure accelerates decomposition and yellowing
- Compatibility: Compatible with anhydrous aprotic solvents; incompatible with reducing agents, strong alkalis, ammonia, amine compounds
3. Main Application Fields
3.1 Pharmaceutical Synthetic Intermediate (Core Usage)
Selective brominating agent for small-molecule APIs, heterocyclic drugs and chiral intermediates; introduces bromine substituent for subsequent coupling reactions.
3.2 Organic Optoelectronic Material Synthesis
Bromination precursor for conjugated polymers, OLED hole transport materials and fluorescent dye skeletons.
3.3 Laboratory Standard Synthetic Reagent
Common radical bromination reagent for university chemical research and fine chemical pilot synthesis.
3.4 Mild Oxidation Auxiliary
Oxidizes secondary alcohols to ketones in neutral solvent system without heavy metal pollution.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 128-08-5 |
| Molecular Formula | C4H4BrNO2 |
| Molecular Weight | 177.98 |
| Appearance | White crystalline powder |
| Melting Range | 172–176 °C (decompose) |
| HPLC Assay | Synthesis Grade ≥98.0%; Pharma Grade ≥99.0% |
| Free Bromine | ≤0.10% |
| Moisture Content (KF) | ≤0.20% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof aluminum foil lined fiber drum |
| Sample Package | 10g / 100g / 1kg sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof cool dry warehouse ≤25℃; isolate humid air, strong light and reducing substances |
| Transportation Rule | Brominated organic reagent; light-proof sealed packaging mandatory during transit |
| Shelf Life | 18 months under intact light-proof sealed packaging |
...
Product
