Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: Adamantan-1-amine hydrochloride
- Aliases: Amantadine HCl, 1-Adamantylamine hydrochloride
- CAS Number: 665-66-7
- EINECS: 211-560-2
- Molecular Formula: C10H18ClN
- Molecular Weight: 187.71
- Chemical Classification: Antiviral & anti-Parkinson API, adamantane derivative pharmaceutical raw material
- Core Advantages
Saturated cage adamantane amine salt. Blocks viral M2 ion channel to inhibit influenza A virus replication; also improves dopamine release for Parkinson’s disease symptomatic relief. High purity meets USP/EP pharmacopoeia standards, used for oral tablet/capsule formulations and pharmaceutical impurity reference standards.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in water, methanol, ethanol; slightly soluble in acetone; insoluble in ether, aliphatic hydrocarbons
- Melting Point: 360–365 °C (sublimation with decomposition)
- Aqueous Solution pH: 4.0–6.0 (weakly acidic)
- Hygroscopy: Slightly hygroscopic under high humidity environment
2.2 Chemical Properties
- Cage adamantane skeleton + ammonium chloride salt structure: Stable rigid hydrocarbon framework, low metabolic toxicity
- Salt dissociation: Dissociates into C10H18N1+ and Cl1- in water; neutralized by alkali to precipitate free 1-adamantanamine
- Acid & Alkali Stability: Stable under neutral and weak acidic conditions; strong alkali releases free adamantylamine
- Thermal Stability: Sublimes at high temperature without massive decomposition
- Photostability: Stable under normal indoor light; avoid long-term intense UV irradiation to prevent discoloration
- Compatibility: Compatible with neutral pharmaceutical excipients; incompatible with strong alkaline substances, heavy metal precipitants
3. Main Application Fields
3.1 Pharmaceutical API (Core Usage)
Active raw material for anti-influenza A oral medicines; also used in preparations for Parkinson disease to relieve tremor and motor dysfunction.
3.2 Pharmaceutical Reference Standard
HPLC calibration standard for amantadine bulk drug and finished dosage form quality control.
3.3 Synthetic Intermediate
Precursor for synthesizing adamantane-based antiviral, anti-diabetic and neuroprotective small-molecule derivatives.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 665-66-7 |
| Molecular Formula | C10H18ClN |
| Molecular Weight | 187.71 |
| Appearance | White crystalline powder |
| Melting Range | 360–365 °C (sublime & decompose) |
| HPLC Assay | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Moisture Content (KF) | ≤0.30% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof nitrogen-sealed aluminum foil lined fiber drum |
| Sample Package | 1g / 10g / 100g sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof cool dry warehouse ≤25℃; isolate humid air, strong light and alkaline materials |
| Transportation Rule | Non-hazardous antiviral API; light-proof waterproof sealed packaging required during transit |
| Shelf Life | 36 months under intact nitrogen-sealed light-proof packaging |
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