Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 1-chloropyrrolidine-2,5-dione
- Aliases: NCS, N-Chlorosuccinimide
- CAS Number: 128-09-6
- EINECS: 204-878-7
- Molecular Formula: C4H4ClNO2
- Molecular Weight: 133.53
- Chemical Classification: Selective chlorinating reagent, mild oxidant, organic synthesis intermediate
- Core Advantages
Stable solid chlorine source with mild reaction activity. Realizes selective electrophilic chlorination of aromatic rings, allylic/benzylic chlorination, alcohol oxidation and sulfur compound chlorination. Low corrosiveness, easy post-treatment, no harsh by-products. Widely applied in pharmaceutical API synthesis, conjugated optoelectronic material preparation and organic chemistry laboratory research.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White crystalline powder
- Odor: Slight chlorine pungent odor
- Solubility: Slightly soluble in water; soluble in THF, DMF, DCM, hot chloroform; insoluble in cold aliphatic alkanes
- Melting Point: 148–152 °C (decomposition)
- Hygroscopy: Slightly hygroscopic, slowly decomposes in humid air releasing chlorine gas
- Crystal Feature: Fine uniform crystals with good dispersion in anhydrous aprotic solvents
2.2 Chemical Properties
- Active N-Cl bond: Under heating or light induction, releases Cl free radical for selective aliphatic chlorination; under polar conditions provides Cl? for aromatic electrophilic substitution
- Selective reactivity: Preferentially chlorinate allylic, benzylic C-H without over-substitution under radical conditions
- Acid & Alkali Stability: Stable under dry neutral environment; hydrolyzes in water to succinimide + hypochlorous acid; violent reaction with strong alkali
- Thermal Stability: Gradually decomposes above 140 °C, emits chlorine vapor
- Photostability: Highly sensitive to strong UV light; long-term illumination causes yellowing and activity loss
- Compatibility: Compatible with anhydrous aprotic solvents; incompatible with reducing agents, ammonia, amines, strong alkaline substances
3. Main Application Fields
3.1 Pharmaceutical Synthetic Intermediate (Core Usage)
Selective chlorinating reagent for heterocyclic APIs, chiral drug intermediates and antibiotic raw materials; introduces chlorine substituents for subsequent coupling derivatization.
3.2 Organic Optoelectronic Material Synthesis
Chlorination precursor for conjugated polymers, fluorescent dyes and OLED functional small molecule skeletons.
3.3 Laboratory Standard Synthetic Reagent
Common selective chlorination reagent for university chemical research and fine chemical pilot amplification.
3.4 Mild Oxidation Auxiliary
Oxidizes sulfide to sulfoxide/sulfone and secondary alcohols to ketones without heavy metal pollution.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 128-09-6 |
| Molecular Formula | C4H4ClNO2 |
| Molecular Weight | 133.53 |
| Appearance | White crystalline powder |
| Melting Range | 148–152 °C (decompose) |
| HPLC Assay | Synthesis Grade ≥98.0%; Pharma Grade ≥99.0% |
| Free Chlorine | ≤0.10% |
| Moisture Content (KF) | ≤0.20% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof aluminum foil lined fiber drum |
| Sample Package | 10g / 100g / 1kg sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof cool dry warehouse ≤25℃; isolate humid air, strong light and reducing substances |
| Transportation Rule | Chlorinated organic reagent; light-proof sealed moisture-proof packaging mandatory during transit |
| Shelf Life | 18 months under intact light-proof sealed packaging |
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