Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 2-methyl-5-nitroimidazol-1-ethanol
- Aliases: Metronidazole, Flagyl
- CAS Number: 443-48-1
- EINECS: 206-415-2
- Molecular Formula: C6H9N3O3
- Molecular Weight: 171.16
- Chemical Classification: Nitroimidazole antibacterial & antiprotozoal API, pharmaceutical raw material
- Core Advantages
Classic nitroimidazole broad-spectrum antimicrobial agent. Effective against anaerobic bacteria, trichomonas, amoeba and giardia. Stable chemical property, good oral absorption, compliant with USP/EP pharmacopoeia standards. Used for oral tablets, injections, topical creams, gynecological suppositories and veterinary antibacterial preparations.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White to pale yellow crystalline powder
- Odor: Odorless, slightly bitter taste
- Solubility: Slightly soluble in water; soluble in ethanol, methanol, chloroform; insoluble in aliphatic hydrocarbons
- Melting Point: 158–160 °C
- Specific Optical Rotation: Optical inactive
- Aqueous suspension pH: 4.5–6.0 (weakly acidic)
- Hygroscopy: Non-hygroscopic under normal dry storage
2.2 Chemical Properties
- Nitroimidazole ring core: Nitro group undergoes reduction under anaerobic environment to generate active metabolites that damage microbial DNA and inhibit reproduction
- Hydroxyl ethyl side chain: Can perform esterification reaction to prepare metronidazole derivatives
- Acid & Alkali Stability: Stable under neutral and weak acidic conditions; decomposes under strong alkaline heating
- Thermal Stability: No obvious decomposition below 140°C
- Photostability: Sensitive to strong UV light; long-term illumination darkens and produces related impurities
- Compatibility: Compatible with most neutral pharmaceutical excipients; incompatible with strong alkali, strong oxidants
3. Main Application Fields
3.1 Human Pharmaceutical API (Core Usage)
- Treat anaerobic bacterial infections in abdominal cavity, oral cavity, gynecology and skin;
- Therapeutic drug for trichomoniasis, intestinal and hepatic amoebiasis, giardiasis;
- Raw material for topical anti-inflammatory cream, gynecological suppository and mouthwash.
3.2 Veterinary Antibacterial Raw Material
Treat livestock and poultry anaerobic infection, protozoal disease of aquatic animals.
3.3 Pharmaceutical Reference Standard
HPLC standard substance for metronidazole preparation quality inspection.
3.4 Fine Chemical Intermediate
Precursor for synthesizing other nitroimidazole antibacterial derivatives.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 443-48-1 |
| Molecular Formula | C6H9N3O3 |
| Molecular Weight | 171.16 |
| Appearance | White crystalline powder |
| HPLC Assay | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Single Maximum Individual Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Moisture Content (KF) | ≤0.30% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof aluminum foil lined fiber drum |
| Sample Package | 1g / 10g / 100g sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof cool dry warehouse ≤25℃; isolate intense light and alkaline materials |
| Transportation Rule | Antibiotic pharmaceutical API; light-proof waterproof sealed packaging required during transit |
| Shelf Life | 36 months under intact light-proof sealed packaging |
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