Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: trans-4-(aminomethyl)cyclohexane-1-carboxylic acid
- Aliases: Amstat, Tranexamic acid, AMCHA, Cyklokapron, Transamin
- CAS Number: 1197-18-8
- EINECS: 214-818-2
- Molecular Formula: C8H15NO2
- Molecular Weight: 157.21
- Chemical Classification: Antifibrinolytic hemostatic API, cosmetic whitening raw material, pharmaceutical amino acid derivative
- Core Advantages
Synthetic trans cyclohexane amino carboxylic acid, competitive inhibitor of plasminogen activation, effectively inhibits abnormal fibrinolysis to stop bleeding. Dual application value: medical hemostasis and skin brightening. High purity meets USP/EP/BP pharmacopoeia standards, low irritation, stable in wide pH range, widely used in hemostatic injections, oral tablets, skin care whitening essence and surgical auxiliary preparations.
Tranexamic Acid Structure
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White crystalline powder
- Odor: Odorless, slightly bitter taste
- Solubility: Freely soluble in water, methanol; slightly soluble in ethanol; insoluble in acetone, ether, aliphatic hydrocarbons
- Melting Point: >300 °C (decomposition without melting)
- Aqueous solution pH (10%): 7.0–8.0 (near neutral)
- Hygroscopy: Non-hygroscopic under normal dry storage
- Optical property: Trans isomer with fixed stereoconfiguration, no racemization under normal conditions
2.2 Chemical Properties
- Amphoteric amino acid structure: Contains amino and carboxyl groups, can form soluble salts with acid/alkali
- Stereostability: Trans configuration maintains hemostatic activity; cis isomer has weak efficacy
- Acid & Alkali Stability: Stable in pH 3–10 range; no degradation under weak acid/weak alkali heating
- Thermal Stability: No decomposition below 280 °C, high thermal processing tolerance
- Photostability: Resistant to UV light, no discoloration in cosmetic formulations
- Compatibility: Compatible with most cosmetic actives, pharmaceutical excipients; incompatible with strong oxidants and heavy metal ions
3. Main Application Fields
3.1 Pharmaceutical API (Core Usage)
- Systemic hemostatic drug for surgical bleeding, postpartum hemorrhage, menorrhagia, traumatic bleeding;
- Oral tablets, intravenous injection, topical hemostatic gauze raw material;
- Auxiliary drug for hemophilia and thrombocytopenia bleeding control.
3.2 Cosmetic Whitening Raw Material
Blocks melanin transfer, fades pigmentation, chloasma, acne marks; added to facial serums, creams, spot essence and medical beauty repair products.
3.3 Medical Dressing Auxiliary
Hemostatic additive for absorbable surgical gauze, wound repair film.
3.4 Pharmaceutical Reference Standard
HPLC calibration standard for tranexamic acid bulk drug and finished dosage quality inspection.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 1197-18-8 |
| Molecular Formula | C8H15NO2 |
| Molecular Weight | 157.21 |
| Appearance | White crystalline powder |
| HPLC Assay | Pharma Grade ≥99.0%; Cosmetic Grade ≥99.5% |
| Cis-Isomer Impurity | ≤0.10% |
| Single Maximum Unknown Impurity | ≤0.05% |
| Total Related Substances | ≤0.30% |
| Moisture Content (KF) | ≤0.20% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤3 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof aluminum foil lined fiber drum |
| Sample Package | 1g / 10g / 100g sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof cool dry warehouse ≤25℃; isolate strong oxidants and acid raw materials |
| Transportation Rule | Non-hazardous pharmaceutical API; light-proof moisture-proof sealed packaging required during transit |
| Shelf Life | 36 months under intact light-proof sealed packaging |
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