Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: (13S,14S,17S)-1,3,5(10)-estratriene-3,17-diol-6-one
- Aliases: 6-Keto-17β-estradiol, 6-Oxoestradiol
- CAS Number: 571-92-6
- EINECS: N/A
- Molecular Formula: C18H22O3
- Molecular Weight: 286.37
- Chemical Classification: Steroid hormone metabolite, estrogen research reference standard, pharmaceutical impurity reference
- Core Advantages
Endogenous oxidative metabolite of estradiol, a key biomarker for estrogen metabolic pathway research. High purity standard grade conforms to laboratory analytical requirements; used for estrogen metabolism mechanism study, LC-MS calibration, steroid drug impurity testing and biochemical pharmacology research. Stable steroid skeleton with ketone substitution at C6 position, unique chromatographic retention property for biological sample detection.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: Off-white to pale beige crystalline powder
- Odor: Odorless
- Solubility: Soluble in methanol, ethanol, acetonitrile, DMSO; slightly soluble in ethyl acetate; insoluble in water, alkane solvents
- Melting Point: 228–232 °C
- Specific Optical Rotation [α]D20: +42° ~ +48° (c=1, ethanol)
- Hygroscopy: Non-hygroscopic under sealed dry storage
- UV Feature: Characteristic absorption peak at 280 nm in alcoholic solution
2.2 Chemical Properties
- Tetracyclic aromatic steroid structure: Phenolic hydroxyl at C3, secondary hydroxyl at C17, ketone carbonyl at C6
- Redox activity: C6 ketone group can be reduced to hydroxyl to form 6-hydroxyestradiol
- Acid & Alkali Stability: Stable under neutral and weak acidic conditions; phenolic group forms salt with strong alkali
- Thermal Stability: No obvious decomposition below 200 °C; high temperature above melting point causes slight degradation
- Photostability: Sensitive to strong UV light; long-term illumination generates oxidation impurities
- Compatibility: Compatible with anhydrous polar organic solvents; incompatible with strong oxidants, concentrated strong base
3. Main Application Fields
3.1 Biochemical & Pharmacology Research (Core Usage)
Standard substance for studying human estrogen metabolic pathway; biomarker for evaluating cytochrome P450 enzyme activity in liver cells.
3.2 Chromatographic Reference Standard
HPLC/UHPLC calibration standard for detecting estrogen metabolites in serum, urine and tissue biological samples.
3.3 Pharmaceutical Impurity Control
Reference standard for related impurity inspection of estradiol bulk drugs and steroid formulations.
3.4 Medical Toxicology Research
Research reagent for exploring estrogen-related oxidative stress and tumor correlation mechanism.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 571-92-6 |
| Molecular Formula | C18H22O3 |
| Molecular Weight | 286.37 |
| Appearance | Off-white crystalline powder |
| Melting Range | 228–232 °C |
| HPLC Purity | Reference Standard ≥99.5%; Research Grade ≥98.0% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Total Related Steroid Impurities | ≤0.50% |
| Moisture Content (KF) | ≤0.20% |
| Heavy Metals (Pb) | ≤5 ppm |
| Residue on Ignition | ≤0.05% |
| Bulk Package | 25kg light-proof nitrogen-sealed aluminum foil lined fiber drum |
| Sample Package | 10mg / 100mg / 1g sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof low-temperature dry warehouse (2–8℃); isolate humid air and strong light |
| Transportation Rule | Steroid research standard; cold-chain light-proof sealed packaging recommended during transit |
| Shelf Life | 36 months under intact nitrogen-sealed low-temperature packaging |
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