Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 2-[(3-trifluoromethyl)phenyl]aminobenzoic acid
- Aliases: Flufenamic acid, FA
- CAS Number: 530-78-9
- EINECS: 208-490-8
- Molecular Formula: C14H10F3NO2
- Molecular Weight: 281.23
- Chemical Classification: Nonsteroidal anti-inflammatory API (NSAID), fenamate class pharmaceutical raw material
- Core Advantages
Fenamate-type NSAID with trifluoromethyl substituted diphenylamine structure. Inhibits prostaglandin synthesis, delivers anti-inflammatory, analgesic and antipyretic effects; also inhibits platelet aggregation. Complies with pharmacopoeia standards, used for oral tablets, external ointments, suppositories for arthritis, soft tissue pain and fever relief.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: Pale yellow crystalline powder
- Odor: Odorless
- Solubility: Soluble in ethanol, acetone, chloroform, DMSO; slightly soluble in hot water; insoluble in cold water and aliphatic hydrocarbons
- Melting Point: 124–126 °C
- Hygroscopy: Non-hygroscopic under dry sealed storage
- UV characteristic: Distinct UV absorption peak in alcoholic solvent
2.2 Chemical Properties
- Dual functional groups: Carboxyl group + secondary aromatic amine; capable of salt formation, esterification reactions
- Trifluoromethyl electron-withdrawing group: Enhances molecular metabolic stability and anti-inflammatory activity
- Acid & Alkali Stability: Stable in neutral and weak acid environments; dissolves in strong alkaline solution to form soluble flufenamate salts; easy discoloration under strong alkali heating
- Thermal Stability: Slow decomposition above 130 °C
- Photostability: Sensitive to strong UV light; long-term illumination darkens and generates oxidation impurities
- Compatibility: Compatible with neutral pharmaceutical excipients; incompatible with concentrated strong alkali, strong oxidants and heavy metal ions
3. Main Application Fields
3.1 Pharmaceutical API (Core Usage)
- Oral anti-inflammatory analgesic raw material for rheumatoid arthritis, osteoarthritis, muscle and joint pain;
- Raw material for external pain relief ointment, rectal suppository to relieve local inflammation and pain;
- Antipyretic preparation for mild fever relief.
3.2 Veterinary Anti-Inflammatory Raw Material
Analgesic and anti-inflammatory medicine for livestock small joint inflammation and traumatic swelling.
3.3 Pharmaceutical Reference Standard
HPLC calibration standard for flufenamic acid bulk drug and finished preparation quality control.
3.4 Synthetic Intermediate
Precursor for synthesizing flufenamate salt derivatives with improved water solubility.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 530-78-9 |
| Molecular Formula | C14H10F3NO2 |
| Molecular Weight | 281.23 |
| Appearance | Pale yellow crystalline powder |
| HPLC Assay | Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Single Maximum Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Moisture Content (KF) | ≤0.30% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof aluminum foil lined fiber drum |
| Sample Package | 1g / 10g / 100g sealed light-proof aluminum foil bag |
| Storage Requirements | Hermetic, light-proof cool dry warehouse ≤25℃; isolate humid air and alkaline substances |
| Transportation Rule | NSAID pharmaceutical API; light-proof moisture-proof sealed packaging mandatory during transit |
| Shelf Life | 36 months under intact light-proof sealed packaging |
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