Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 4-fluorophenol
- Aliases: p-Fluorophenol, 4-FP
- CAS Number: 371-41-5
- EINECS: 207-434-3
- Molecular Formula: C6H5FO
- Molecular Weight: 112.10
- Chemical Classification: Fluorinated aromatic intermediate, pharmaceutical & pesticide synthetic raw material
- Core Advantages
Para-substituted fluorophenol with electron-withdrawing fluorine atom on benzene ring. Unique electronic and steric properties improve metabolic stability and biological activity of target molecules. Key building block for fluorinated APIs, herbicides, liquid crystal materials and dye intermediates; available in industrial & high-purity electronic grades.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: Colorless to pale white crystalline solid
- Odor: Characteristic phenolic irritating odor
- Solubility: Slightly soluble in water; miscible with ethanol, methanol, acetone, DCM, toluene
- Melting Point: 46–48 °C
- Boiling Point: 186–188 °C
- Density (50℃ liquid): 1.178 g/cm3
- Hygroscopy: Slightly hygroscopic, easy to discolor in humid air
- Aqueous solution: Weak acidity, turns blue litmus red
2.2 Chemical Properties
- Phenolic hydroxyl group: Reacts with alkali to form 4-fluorophenoxide salts; undergoes esterification, etherification
- Aromatic ring fluorine substitution: Fluorine activates ortho/para positions for electrophilic substitution; stable against hydrolysis under neutral conditions
- Acid & Alkali Stability: Stable under weak acid; dissolves in strong alkali solution; strong oxidants trigger ring oxidation
- Thermal Stability: No decomposition below 160°C; slight volatile loss under long-time heating
- Photostability: Turns pink/brown under long-term UV irradiation, generates phenolic oxidation impurities
- Compatibility: Compatible with neutral aprotic solvents; incompatible with strong oxidants, heavy metal salts, concentrated alkali
3. Main Application Fields
3.1 Pharmaceutical Intermediate (Core Usage)
Skeleton raw material for fluorinated antibacterial, anti-inflammatory, cardiovascular and central nervous system drugs; fluorine modification enhances drug bioavailability and reduces side effects.
3.2 Pesticide & Herbicide Intermediate
Building block for high-efficiency low-toxic fluorinated herbicides, fungicides and insecticides.
3.3 Electronic Liquid Crystal Material
Monomer raw material for fluorinated liquid crystal monomers, improves dielectric anisotropy and low-temperature performance of display materials.
3.4 Fine Chemical Dye Intermediate
Precursor for synthesizing high light-fastness fluorinated disperse dyes and functional fluorescent dyes.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 371-41-5 |
| Molecular Formula | C6H5FO |
| Molecular Weight | 112.10 |
| Appearance | White crystalline solid |
| GC Purity | Industrial ≥98.0%; High Purity ≥99.5% |
| Water Content (KF) | ≤0.20% |
| Phenol Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Residue on Evaporation | ≤0.05% |
| Bulk Package | 25kg PE lined fiber drum |
| Sample Package | 1kg / 5kg sealed plastic bucket |
| Storage Requirements | Hermetic cool dry warehouse ≤25℃; isolate sunlight, humid air and oxidants |
| Transportation Rule | Corrosive phenolic fluorinated intermediate; sealed acid-resistant packaging required during transit |
| Shelf Life | 18 months under intact sealed packaging |
...
Product
