Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: diethyl propanedioate
- Aliases: DEM, Ethyl malonate, Malonic acid diethyl ester
- CAS Number: 105-53-3
- EINECS: 203-305-8
- Molecular Formula: C7H12O4
- Molecular Weight: 160.17
- Chemical Classification: β-dicarbonyl active methylene synthetic intermediate, malonate synthesis raw material
- Core Advantages
Typical active methylene compound with two adjacent ester carbonyl groups. The central CH? shows strong acidity, easily deprotonated by alkalis to form enolate anions for Michael addition, alkylation, Knoevenagel condensation, malonic ester synthesis. Widely used for pharmaceutical APIs, flavor fragrances, agrochemicals, polymer additives and laboratory organic synthesis.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: Colorless clear oily liquid
- Odor: Mild sweet fruity ester odor
- Solubility: Slightly soluble in water; fully miscible with ethanol, methanol, acetone, ethyl acetate, benzene, chloroform
- Boiling Point: 198–200 °C
- Melting Point: -50 °C
- Density (20℃): 1.055 g/cm3
- Refractive Index nD20: 1.414–1.416
- Hygroscopy: Non-hygroscopic, low volatility at room temperature
2.2 Chemical Properties
- Active methylene feature: Central hydrogen atoms have pKa ≈13, reacts with sodium ethoxide, NaH, LDA to generate nucleophilic enolate
- Hydrolysis reaction: Saponified under acid/alkali heating to malonic acid, decarboxylates upon strong heating to acetic acid
- Condensation reactivity: Undergoes Knoevenagel with aldehydes/ketones; alkylation with alkyl halides; Michael addition with α,β-unsaturated carbonyl compounds
- Ester exchange: Transesterification with other alcohols under acid catalysis
- Acid & Alkali Stability: Stable under neutral anhydrous conditions; rapid hydrolysis in aqueous alkali with heating
- Thermal Stability: Slow decarboxylation above 180 °C; no decomposition under normal storage temperature
- Compatibility: Compatible with most anhydrous organic solvents; incompatible with strong aqueous bases, strong oxidants
3. Main Application Fields
3.1 Pharmaceutical Intermediate (Core Usage)
Key building block for synthesizing barbiturates, anti-inflammatory drugs, vitamin B1, antibiotics, anti-epileptic and cardiovascular pharmaceutical intermediates via malonate alkylation and cyclization.
3.2 Flavor & Fragrance Industry
Synthetic raw material for fruit flavor esters, aromatic aldehyde condensation fragrances, food additives and daily perfume formulations.
3.3 Agrochemical Intermediates
Precursor for manufacturing herbicides, fungicides and insecticide molecular skeletons with carboxylic acid functional groups.
3.4 Polymer & Coating Auxiliaries
Crosslinking agent, curing auxiliary and raw material for polyester resins, alkyd coatings and adhesive modifiers.
3.5 Laboratory Synthetic Reagent
Universal active methylene reagent for multi-step organic synthesis and fine chemical pilot process development.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 105-53-3 |
| Molecular Formula | C7H12O4 |
| Molecular Weight | 160.17 |
| Appearance | Colorless transparent liquid |
| GC Purity | Industrial Grade ≥99.0%; Synthetic Grade ≥99.5% |
| Water Content (KF) | ≤0.10% |
| Free Acid (Malonic acid) | ≤0.05% |
| Residue on Evaporation | ≤0.01% |
| Bulk Package | 200L plastic-lined iron drum, 1000L IBC tank |
| Sample Package | 1L / 5L sealed plastic bottle |
| Storage Requirements | Hermetic cool dry warehouse ≤25℃; isolate strong alkaline substances and direct sunlight |
| Transportation Rule | Non-corrosive ester intermediate; sealed waterproof packaging required during transit |
| Shelf Life | 24 months under intact sealed packaging |
...
Product
