Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 3-hydroxy-4-methoxyphenylmethanol
- Aliases: Isovanillyl alcohol, 4-methoxy-3-hydroxybenzyl alcohol
- CAS Number: 4383-06-6
- EINECS: 224-489-4
- Molecular Formula: C8H10O3
- Molecular Weight: 154.16
- Chemical Classification: Natural phenolic aromatic intermediate, cosmetic antioxidant raw material, pharmaceutical synthetic building block
- Core Advantages
Phenolic benzyl alcohol with ortho hydroxyl-methoxy structure (isovanillin skeleton reduced form). Excellent free radical scavenging antioxidant capacity, mild skin-friendly activity. Dual reactive hydroxyl groups (phenolic hydroxyl + benzyl primary alcohol) support esterification, etherification, oxidation and coupling reactions. Widely used in cosmetic anti-aging formulations, natural product synthesis, flavor intermediates and pharmaceutical API development.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White to off-white crystalline powder
- Odor: Mild faint vanilla-like aroma
- Solubility: Slightly soluble in cold water, soluble in hot water; freely soluble in ethanol, methanol, acetone, ethyl acetate, DMSO; slightly soluble in toluene
- Melting Point: 130–133 °C
- Hygroscopy: Non-hygroscopic under dry sealed storage
- UV Characteristic: Strong UV absorption in 280–320 nm range
- Aqueous solution: Weak acidity from phenolic hydroxyl
2.2 Chemical Properties
- Multi-hydroxyl functional system: Phenolic -OH at C3, methoxy -OCH3 at C4, primary benzyl alcohol -CH2OH at C1
- Antioxidant activity: Ortho methoxy group stabilizes phenolic free radical, superior anti-oxidation to simple phenols
- Oxidation reaction: Benzyl alcohol can be oxidized to isovanillin; phenolic hydroxyl easily oxidizes under strong light/air to form quinone impurities
- Esterification & etherification: Both phenolic and aliphatic hydroxyl groups react with acyl halides, alkyl halides to produce derivatives
- Acid & Alkali Stability: Stable in weak acid/neutral medium; phenolic hydroxyl forms salt with strong alkali; long-term heating in strong alkali causes slight degradation
- Thermal Stability: Stable below 120°C; slow oxidation discoloration above melting point
- Photostability: Sensitive to strong UV light, easy yellowing with prolonged illumination
- Compatibility: Compatible with most cosmetic oils, surfactants and pharmaceutical excipients; incompatible with strong oxidants, heavy metal ions
3. Main Application Fields
3.1 Cosmetic Raw Material (Core Usage)
High-efficiency natural antioxidant for anti-aging essence, facial cream, mask and sunscreen; inhibits free radical damage, reduces melanin oxidation, soothes sensitive skin; replaces synthetic antioxidants for clean beauty formulations.
3.2 Pharmaceutical Intermediate
Synthetic precursor for cardiovascular, anti-inflammatory and neuroprotective drugs; raw material for preparing polyphenol derivatives with antioxidant and neuroprotective efficacy.
3.3 Flavor & Fragrance Intermediate
Vanilla series flavor modifier, used in food and daily fragrance synthesis to enrich creamy sweet aroma.
3.4 Natural Product Chemistry Research
Standard phenolic reference substance for plant secondary metabolite extraction and activity screening.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 4383-06-6 |
| Molecular Formula | C8H10O3 |
| Molecular Weight | 154.16 |
| Appearance | White crystalline powder |
| HPLC Purity | Cosmetic Grade ≥99.0%; Pharma Grade ≥99.5% |
| Moisture Content (KF) | ≤0.30% |
| Isovanillin Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤3 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg aluminum foil lined fiber drum |
| Sample Package | 100g / 1kg sealed light-proof plastic bottle |
| Storage Requirements | Hermetic light-proof dry warehouse ≤25℃; isolate air, strong oxidants and direct sunlight |
| Transportation Rule | Non-hazardous phenolic intermediate; light-proof moisture-proof sealed packaging required during transit |
| Shelf Life | 24 months under intact light-proof sealed packaging |
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