Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: (22R,25R)-spirost-5-en-3β-ol
- Aliases: Diosgenine, Diosgenol
- CAS Number: 512-04-9
- EINECS: 208-134-3
- Molecular Formula: C27H42O3
- Molecular Weight: 414.62
- Chemical Classification: Natural steroidal sapogenin, core steroid pharmaceutical intermediate, plant extract raw material
- Core Advantages
Key natural spirostan sapogenin extracted from Dioscorea, Smilax and fenugreek. The universal starting material for nearly all synthetic steroid drugs (progestogens, estrogens, corticosteroids, androgens). Possesses anti-inflammatory, lipid-regulating, anti-oxidation pharmacological activity itself, applied in pharmaceutical synthesis, health care raw materials and cosmetic anti-aging ingredients. High stereochemical purity, stable tetracyclic steroid skeleton with double bond and hydroxyl group for multi-step derivatization.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White or off-white crystalline powder
- Odor: Odorless
- Solubility: Insoluble in water; soluble in chloroform, ethanol, methanol, acetone, ethyl acetate; slightly soluble in vegetable oil
- Melting Point: 204–207 °C
- Specific Optical Rotation [α]D20: -120° ~ -130° (c=1, chloroform)
- Hygroscopy: Non-hygroscopic under sealed dry storage
- UV characteristic: Weak absorption peak at 235 nm from C5-C6 double bond
2.2 Chemical Properties
- Spirostan steroid skeleton: 3β-hydroxyl group, Δ5 carbon-carbon double bond, characteristic spiroketal side chain at C22/C25
- Hydroxyl reactivity: 3-OH undergoes esterification, acylation, oxidation to form ketodiosgenin
- Double bond modification: Catalytic hydrogenation to dihydrodiosgenin; epoxidation, addition reactions
- Spiroketal ring cleavage: Acid hydrolysis opens spiro ring to produce pseudodiosgenin, the critical step for steroid nucleus side chain reconstruction
- Acid & Alkali Stability: Stable in neutral and weak alkaline environments; concentrated mineral acid triggers spiroketal hydrolysis; strong alkali does not damage steroid backbone
- Thermal Stability: No decomposition below 190 °C; above melting point slow oxidation discoloration
- Photostability: Slightly yellow after long-term intense UV irradiation
- Compatibility: Compatible with most organic solvents and neutral pharmaceutical excipients; incompatible with strong mineral acids, strong oxidants
3. Main Application Fields
3.1 Steroid Pharmaceutical Intermediate (Core Usage)
Universal starting raw material for synthesizing all classes of steroid APIs: progesterone, estradiol, prednisone, dexamethasone, testosterone, contraceptive steroids; the foundational material of global steroid drug industry.
3.2 Health Care & Nutraceutical Raw Material
Regulates blood lipid, improves menopausal discomfort, anti-oxidation and anti-inflammatory health food additive; relieves joint inflammation.
3.3 Cosmetic Functional Raw Material
Anti-aging, anti-inflammatory active ingredient for facial cream and repair lotion; improves skin barrier and inhibits inflammatory erythema.
3.4 Biochemical Reference Standard
HPLC reference standard for sapogenin detection in plant extracts and Chinese herbal medicine quality control.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 512-04-9 |
| Molecular Formula | C27H42O3 |
| Molecular Weight | 414.62 |
| Appearance | White crystalline powder |
| HPLC Assay | Synthetic Grade ≥98.0%; Pharma Grade ≥99.0%; Reference Standard ≥99.5% |
| Melting Point Range | 204–207 °C |
| Moisture Content (KF) | ≤0.30% |
| Total Steroid Impurities | ≤0.50% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤3 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg light-proof aluminum foil lined fiber drum |
| Sample Package | 1g / 10g / 100g sealed light-proof plastic bottle |
| Storage Requirements | Hermetic light-proof dry warehouse ≤25℃; isolate strong acid, oxidants and direct sunlight |
| Transportation Rule | Non-hazardous natural steroid intermediate; moisture-proof light-proof packaging required during transit |
| Shelf Life | 36 months under intact light-proof sealed packaging |
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