1. Basic Product Profile

• Full IUPAC Name: Hyaluronan, Sodium Hyaluronate (Common Commercial Form)
• Aliases: HA, Hyaluronan, Hyaluronic acid sodium salt
• CAS Number: 9004-61-9
• EINECS: 232-678-0
• Molecular Formula: Repeating unit: C14H20NNaO11 n
• Molecular Weight: Variable (10 kDa ~ 3,000 kDa depending on grade)
• Chemical Classification: Natural high-molecular glycosaminoglycan, biological moisturizer, cosmetic active, medical biomaterial, pharmaceutical excipient
• Core Advantages
  Linear polysaccharide composed of alternating D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units. Extremely strong water-binding capacity, excellent biocompatibility, non-irritating to human tissue. Multi molecular weight grades for different applications: high MW for surface moisturizing, medium MW for skin penetration, low MW & ultra-low MW for deep repair, injection grade for medical filling. Widely used in skincare, ophthalmic preparations, joint injection, medical wound dressings and oral health care products.

2. Physical & Chemical Properties

2.1 Physical Index

1. Appearance: White to off-white fibrous powder
2. Odor: Odorless
3. Solubility: Easily soluble in pure water; insoluble in ethanol, acetone, oils and organic solvents
4. Solution Viscosity: Highly viscous aqueous solution, viscosity positively correlated with molecular weight
5. pH (0.1% aqueous solution): 6.0–7.5 (near neutral, skin-friendly)
6. Hygroscopy: Strongly hygroscopic, rapidly absorbs moisture from air
7. Film-forming property: Forms transparent elastic moisturizing film on skin surface after water evaporation

2.2 Chemical Properties

1. Polysaccharide structure: Massive hydroxyl, carboxyl and acetamide groups, powerful water retention
2. Salt formation: Carboxyl groups combine with sodium ions to form sodium hyaluronate (commercial mainstream form)
3. Degradation characteristic: Degraded by hyaluronidase enzyme; high temperature, strong acid/alkali break long molecular chains and reduce viscosity
4. Acid & Alkali Stability: Stable at pH 5–8; severe chain cleavage below pH 4 or above pH 10
5. Thermal Stability: Stable below 60℃; prolonged heating above 80℃ causes molecular weight decline and viscosity loss
6. Photostability: Long-term strong UV irradiation accelerates oxidative degradation
7. Compatibility: Compatible with most cosmetic raw materials, neutral pharmaceutical excipients; incompatible with strong oxidants, high-concentration acid/alkali, cationic preservatives in excessive dosage

3. Main Application Fields

3.1 Cosmetic & Personal Care (Core Usage)

1. High molecular weight HA: Surface moisturizer, locks water, forms protective film to reduce transepidermal water loss;
2. Medium molecular weight HA: Penetrates intercellular space, improves skin softness and elasticity;
3. Low/ultra-low molecular HA: Deep epidermal repair, anti-aging, anti-inflammatory, relieves sensitive redness;
4. Raw material for essence, facial mask, cream, eye gel, shampoo and body lotion.

3.2 Medical & Pharmaceutical Grade

1. Ophthalmology: Intraocular viscoelastic agent for cataract surgery, artificial eye drops for dry eye relief;
2. Orthopedics: Intra-articular injection for osteoarthritis lubrication and pain relief;
3. Medical aesthetics: Dermal filler for wrinkle filling, contour shaping;
4. Wound dressing: Promotes skin tissue repair, accelerates ulcer healing.

3.3 Food & Oral Health Grade

3.4 Biochemical Research Reagent

4. Quality Specification Table