Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: (2R)-2-amino-3-hydroxypropanoic acid
- Aliases: D-2-Amino-3-hydroxypropionic acid, D-Ser
- CAS Number: 312-84-5
- EINECS: 206-220-6
- Molecular Formula: C3H7NO3
- Molecular Weight: 105.09
- Chemical Classification: Chiral non-proteinogenic amino acid, biochemical reagent, pharmaceutical intermediate, central nervous system research raw material
- Core Advantages
D-configured chiral serine with side chain hydroxyl group, stereoisomer of natural L-serine. It acts as a co-agonist of NMDA receptors in the mammalian brain, widely used in neuroscience research, psychotropic drug intermediates, cell culture medium and chiral synthesis building blocks. High chiral purity, stable crystal form, moderate water solubility.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in water; slightly soluble in hot ethanol; insoluble in acetone, ether, alkane solvents
- Melting Point: 228–230 °C (decomposition)
- Specific Optical Rotation [α]D20: -14.0° ~ -16.0° (c=10, 1mol/L HCl)
- pH (5% aqueous solution): 5.4–6.5 (weakly acidic)
- Hygroscopy: Slightly hygroscopic under high humidity
2.2 Chemical Properties
- Functional groups: α-amino, carboxyl and primary hydroxyl side chain, typical amphoteric chiral amino acid
- Amphoteric characteristic: Forms inner salt in water; reacts with inorganic acids/bases to generate corresponding amino acid salts
- Hydroxyl reactivity: Side chain -OH supports esterification, etherification and protection reactions for chiral drug synthesis
- Peptide condensation: Amino group couples with carboxylic acids to construct D-amino acid containing peptide chains
- Thermal Stability: Stable below 200°C; decomposes above melting point to release ammonia
- Acid & Alkali Stability: Stable in weak acid/neutral environment; long-term heating with strong alkali causes side chain dehydration
- Photostability: No discoloration under normal light storage
- Compatibility: Compatible with aqueous buffer, polar solvents; incompatible with strong oxidants, concentrated strong acid
3. Main Application Fields
3.1 Neuroscience Biochemical Research (Core Usage)
- NMDA receptor experimental reagent for brain nerve, schizophrenia and cognitive disorder mechanism research;
- Standard chiral reference substance for D-amino acid detection and chromatographic calibration.
3.2 Pharmaceutical Intermediate
- Chiral precursor for central nervous system targeted drugs, antidepressant and neuroprotective agents;
- Raw material for chiral antibiotics and peptide APIs containing D-serine fragments.
3.3 Microbial Fermentation & Cell Culture
Special medium additive for strains that metabolize D-amino acids; neural cell culture supplement.
3.4 Asymmetric Synthetic Reagent
Chiral building block for asymmetric organic synthesis, chiral ligand preparation.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 312-84-5 |
| Molecular Formula | C3H7NO3 |
| Molecular Weight | 105.09 |
| Appearance | White crystalline powder |
| HPLC Chiral Purity | Lab Grade ≥99.0%; Pharma Synthetic Grade ≥99.5% |
| Moisture Content (KF) | ≤0.30% |
| Specific Optical Rotation | -14.0° ~ -16.0° |
| L-Serine Enantiomer Impurity | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg PE lined fiber drum |
| Sample Package | 100g / 1kg light-proof sealed plastic bottle |
| Storage Requirements | Hermetic cool dry warehouse ≤25℃; isolate humid air, strong oxidants and direct sunlight |
| Transportation Rule | Non-hazardous chiral amino acid reagent; moisture-proof sealed packaging required during transit |
| Shelf Life | 36 months under intact sealed packaging |
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