Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 1-deoxy-1-(methylamino)-D-glucitol
- Aliases: N-Methyl-D-glucamine, Methylglucamine
- CAS Number: 6284-40-8
- EINECS: 228-506-9
- Molecular Formula: C7H17NO5
- Molecular Weight: 195.21
- Chemical Classification: Polyhydroxy alkylamine, pharmaceutical excipient, contrast medium raw material, solubility booster, analytical reagent
- Core Advantages
Polyhydroxy chiral amine derived from D-glucose, with multiple hydroxyl groups and a secondary methylamino group. Excellent water solubility, strong ability to form soluble salts with acidic drugs, low toxicity and high biocompatibility. Widely used to prepare meglumine salt APIs (anti-inflammatory, contrast agents), solubilizer for poorly soluble pharmaceuticals, pH buffer stabilizer, and analytical chromatography additive.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White crystalline powder
- Odor: Odorless
- Solubility: Freely soluble in water; soluble in hot methanol; slightly soluble in cold ethanol; insoluble in acetone, ether, hydrocarbons
- Melting Point: 128–132 °C
- Specific Optical Rotation [α]D20: -16.0° ~ -18.0° (c=10, water)
- pH (10% aqueous solution): 9.0–10.5 (weakly alkaline)
- Hygroscopy: Moderately hygroscopic, absorbs moisture in high humidity air
2.2 Chemical Properties
- Functional groups: 5 aliphatic hydroxyl groups + secondary methylamino group, chiral polyhydroxy amine structure
- Salt-forming characteristic: Secondary amine reacts with organic/inorganic acids to generate highly water-soluble meglumine salts (core application for contrast media & injectable drugs)
- Hydroxyl reactivity: Multiple -OH groups enable esterification, chelation with metal ions, strong hydrogen bonding for solubilization
- Thermal Stability: Stable below 110°C; prolonged heating above melting point triggers slight caramelization yellowing
- Acid & Alkali Stability: Stable in neutral/weak alkaline environment; concentrated strong acid heating causes sugar backbone hydrolysis
- Photostability: Slightly yellow after long-term intense UV irradiation
- Compatibility: Compatible with water-soluble pharmaceutical raw materials, polar solvents; incompatible with strong oxidants, concentrated mineral acids
3. Main Application Fields
3.1 Medical Contrast Medium Raw Material (Core Usage)
Synthesis precursor for iodinated X-ray contrast agents (meglumine diatrizoate, meglumine ioxitalamate); improves water solubility of iodine-containing contrast molecules for intravenous radiography.
3.2 Pharmaceutical Excipient & Drug Solubilizer
- Form meglumine salt with poorly water-soluble acidic active pharmaceutical ingredients (NSAIDs, antibiotics) to boost solubility for oral/injectable formulations;
- pH regulator and stabilizer for injection solutions, reduces irritation to blood vessels.
3.3 Analytical & Biochemical Reagent
- Mobile phase additive for ion-exchange chromatography;
- Chelating agent for trace metal detection experiments;
- Standard reference for sugar amine chiral analysis.
3.4 Fine Chemical Synthesis
Chiral polyol building block for asymmetric synthesis and water-soluble functional polymer preparation.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 6284-40-8 |
| Molecular Formula | C7H17NO5 |
| Molecular Weight | 195.21 |
| Appearance | White crystalline powder |
| HPLC Purity | Pharma Grade ≥99.0%; Injection Grade ≥99.5% |
| Moisture Content (KF) | ≤0.30% |
| Specific Optical Rotation | -16.0° ~ -18.0° |
| Heavy Metals (Pb) | ≤10 ppm (Injection Grade ≤2 ppm) |
| Arsenic (As) | ≤2 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg aluminum foil lined fiber drum |
| Sample Package | 1kg / 5kg sealed moisture-proof plastic bucket |
| Storage Requirements | Hermetic cool dry warehouse ≤25℃; isolate humid air, strong oxidants and direct sunlight |
| Transportation Rule | Non-hazardous pharmaceutical amine raw material; moisture-proof sealed packaging required during transit |
| Shelf Life | 36 months under intact sealed packaging |
...
Product
