Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Product Profile
- Full IUPAC Name: 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
- Aliases: Fluconazole, UK-49858
- CAS Number: 86386-73-4
- EINECS: N/A
- Molecular Formula: C13H12F2N6O
- Molecular Weight: 306.28
- Chemical Classification: Triazole antifungal API, pharmaceutical raw material, broad-spectrum antifungal intermediate
- Core Advantages
Difluorophenyl bis-triazole antifungal active pharmaceutical ingredient with high oral bioavailability, broad-spectrum inhibitory activity against Candida, Cryptococcus and dermatophytes. Low liver toxicity, excellent water solubility for oral tablets, capsules and intravenous injection formulations. Widely used in systemic fungal infection treatment, gynecological mycosis, skin fungal disease and cryptococcal meningitis therapy. Stable crystal form, high chiral purity, easy formulation processing.
2. Physical & Chemical Properties
2.1 Physical Index
- Appearance: White or off-white crystalline powder
- Odor: Odorless
- Solubility: Slightly soluble in water; freely soluble in methanol, ethanol, acetone, chloroform; insoluble in alkane solvents
- Melting Point: 137–141 °C
- pH (saturated aqueous solution): 6.0–7.2 (neutral)
- Hygroscopy: Non-hygroscopic under normal dry storage
- UV characteristic: Characteristic absorption peak at 261 nm
2.2 Chemical Properties
- Functional groups: Two 1,2,4-triazole rings, difluorobenzene ring, tertiary hydroxyl group
- Triazole ring activity: Nitrogen atoms on triazole form hydrogen bonds with fungal cytochrome P450 enzyme to inhibit ergosterol synthesis
- Hydroxyl stability: Tertiary hydroxyl group stable under neutral/weak acid/weak alkali; no dehydration under conventional storage
- Fluorine substitution: Aromatic C-F bonds stable, resistant to hydrolysis under mild conditions
- Thermal Stability: Stable below 120°C; prolonged heating above melting point causes slight decomposition
- Acid & Alkali Stability: Stable pH 3–9; concentrated strong acid long-time heating triggers triazole ring hydrolysis
- Photostability: Slightly yellow after long-term intense UV irradiation; store light-proof
- Compatibility: Compatible with common pharmaceutical excipients; incompatible with strong oxidants, concentrated mineral acids
3. Main Application Fields
3.1 Human Antifungal API (Core Usage)
- Oral preparations: Tablets, capsules, oral suspension for systemic candidiasis, vaginal candidiasis, skin tinea infection;
- Injectable formulations: IV fluconazole injection for severe systemic fungal infection, cryptococcal meningitis;
- Prophylactic antifungal medicine for immunocompromised patients.
3.2 Veterinary Pharmaceutical Raw Material
Veterinary antifungal drug for livestock and pet fungal skin disease, poultry candidiasis control.
3.3 Biochemical Research Reagent
Fungal cell culture inhibitor, experimental positive control for antifungal drug screening.
3.4 Synthetic Intermediate Reference
Standard reference substance for triazole antifungal synthetic route research and HPLC quality control.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS No. | 86386-73-4 |
| Molecular Formula | C13H12F2N6O |
| Molecular Weight | 306.28 |
| Appearance | White crystalline powder |
| HPLC Assay | Pharma Grade ≥99.0%; USP/EP Grade 98.0%–102.0% |
| Moisture Content (KF) | ≤0.30% |
| Single Unknown Impurity | ≤0.10% |
| Total Related Substances | ≤0.50% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg aluminum foil lined fiber drum |
| Sample Package | 1kg / 5kg light-proof sealed plastic bucket |
| Storage Requirements | Hermetic light-proof cool dry warehouse ≤25℃; isolate humid air, high temperature and strong UV light |
| Transportation Rule | Non-hazardous antifungal API; light-proof moisture-proof sealed packaging required during transit |
| Shelf Life | 36 months under intact sealed packaging |
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