1. Basic Product Profile

• Full IUPAC Name: Chondroitin sulfate sodium
• Aliases: CS, Chondroitin sodium sulfate
• CAS Number: 9007-28-7
• EINECS: 232-694-6
• Molecular Formula: Repeating unit C14H19NNaO14S
• Molecular Weight: Variable (10 kDa ~ 80 kDa depending on raw material source)
• Chemical Classification: Natural sulfated glycosaminoglycan, joint health nutritional raw material, cosmetic moisturizing active, medical biomaterial excipient
• Core Advantages
  Natural linear polysaccharide extracted from animal cartilage, composed of alternating D-glucuronic acid and N-acetyl-D-galactosamine disaccharide units with sulfate groups. Strong water retention, excellent lubricating and anti-inflammatory activity. Widely combined with glucosamine for joint health supplements; also used in eye drops, wound repair dressings and anti-aging skincare products. Good biocompatibility, low irritation, stable sodium salt form for easy formulation.

2. Physical & Chemical Properties

2.1 Physical Index

1. Appearance: White to off-white fibrous powder
2. Odor: Odorless
3. Solubility: Easily soluble in pure water; insoluble in ethanol, acetone, oils and organic solvents
4. Solution Property: Forms highly viscous transparent aqueous solution
5. pH (0.1% aqueous solution): 6.0–7.5 (neutral, skin & tissue friendly)
6. Hygroscopy: Strongly hygroscopic, rapidly absorbs moisture from air
7. Film-forming property: Forms flexible moisturizing protective film on skin surface

2.2 Chemical Properties

1. Polysaccharide structure: Rich in hydroxyl, carboxyl, acetamide and sulfate groups, powerful water-locking capacity
2. Salt characteristic: Commercial product is sodium chondroitin sulfate, stable ionic form
3. Degradation rule: Degraded by chondroitinase enzyme; high temperature, strong acid/alkali break polysaccharide chains and reduce viscosity
4. pH stability: Stable within pH 5–8; severe molecular chain cleavage below pH 4 or above pH 10
5. Thermal stability: Stable below 60°C; prolonged heating above 80°C leads to molecular weight decline
6. Photostability: Long-term strong UV irradiation accelerates oxidative degradation
7. Compatibility: Compatible with most cosmetic raw materials, nutritional supplements; incompatible with high-concentration acid/alkali, excessive cationic preservatives, strong oxidants

3. Main Application Fields

3.1 Health & Joint Nutritional Supplements (Core Usage)

1. Compound raw material with glucosamine: Lubricates articular cartilage, relieves joint pain, slows cartilage wear for elderly and sports crowd;
2. Oral capsule, tablet, functional beverage raw material for bone joint care.

3.2 Medical & Pharmaceutical Grade

1. Artificial tear eye drops: Relieves dry eye, lubricates ocular surface;
2. Medical wound dressing: Promotes skin cartilage tissue repair, reduces inflammatory swelling;
3. Injection auxiliary raw material for orthopedic joint lubrication preparations.

3.3 Cosmetic & Personal Care Raw Material

3.4 Biochemical Research Reagent

4. Quality Specification Table