1. Basic Product Profile

• Full IUPAC Name: Pyridine-4-carbaldehyde
• Aliases: 4-Formylpyridine, p-Pyridinecarboxaldehyde
• CAS Number: 872-85-5
• EINECS: 212-823-0
• Molecular Formula: C6H5NO
• Molecular Weight: 107.11
• Chemical Classification: Aromatic nitrogen heterocyclic aldehyde, pharmaceutical intermediate, organic synthetic building block, chelating ligand raw material
• Core Advantages
  Pyridine ring with aldehyde group at para position, dual reactive functional groups of pyridine nitrogen and aromatic aldehyde. Participates in aldol condensation, imine formation, reductive amination, cyclization reactions. Key skeleton raw material for cardiovascular, anti-tumor, antibacterial small-molecule APIs, metal organic framework (MOF) ligands and chiral catalyst precursors. Moderate solubility in polar solvents, stable under light-proof sealed storage.

2. Physical & Chemical Properties

2.1 Physical Index

1. Appearance: Pale yellow to light amber transparent oily liquid
2. Odor: Pungent aromatic aldehyde odor
3. Solubility: Soluble in water, ethanol, methanol, acetone, dichloromethane; slightly soluble in benzene; insoluble in aliphatic alkanes
4. Boiling Point: 198–200 °C
5. Melting Point: 0–2 °C
6. Density (20℃): 1.120–1.126 g/cm3
7. Refractive Index nD20: 1.540–1.546
8. pH (aqueous solution): Weakly acidic
9. Hygroscopy: Slightly hygroscopic under high humidity air

2.2 Chemical Properties

1. Functional structure: Pyridine aromatic heterocycle with para-position -CHO aldehyde group
2. Aldehyde reactivity: Condenses with amines to form Schiff base imines; undergoes oxidation to 4-pyridinecarboxylic acid, reduction to 4-pyridinemethanol
3. Pyridine nitrogen activity: Coordinates with transition metal ions (Cu, Zn, Ni, Fe) to construct metal complex catalysts and MOF materials
4. Thermal Stability: Stable below 160℃; long-term high-temperature heating induces self-polymerization
5. Acid & Alkali Stability: Stable in neutral and weak acid; prone to aldol polymerization under strong alkaline heating
6. Photostability: Gradually darkens and generates polymer impurities under long-term UV/air exposure; light-proof storage mandatory
7. Compatibility: Compatible with polar protic & aprotic solvents; incompatible with strong oxidants, concentrated strong alkali

3. Main Application Fields

3.1 Pharmaceutical Intermediate (Core Usage)

1. Schiff base precursor for antibacterial, anti-inflammatory, anti-tumor heterocyclic drug synthesis;
2. Raw material for nicotinic acid derivative APIs, nervous system and cardiovascular small-molecule medicines;
3. Chiral ligand intermediate for asymmetric synthetic drug routes.

3.2 Coordination Chemistry & Material Synthesis

1. Organic ligand for MOFs, metal coordination complexes and photocatalytic catalyst preparation;
2. Chelating agent building block for industrial metal ion separation and wastewater treatment auxiliaries.

3.3 Organic Synthetic Research Reagent

3.4 Fine Chemical Additive

4. Quality Specification Table