Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: Cannabigerol
Alias: CBG, 2-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-5-pentylbenzene-1,3-diol,
CAS No.: 25654-31-3
Molecular Formula: C21H32O2
Molecular Weight: 316.48
2. Physical & Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Faint natural herbal terpene odor
- Solubility: Freely soluble in ethanol, DMSO, methanol, chloroform, hexane; insoluble in water; high lipophilicity (LogP=7.47)
- Melting Point: 49–50 °C
- Boiling Point: 470.4±40.0 °C (760 mmHg, predicted)
- Density (25℃): 0.987–1.00 g/cm3
- Refractive Index nD2?: 1.536
- Flash Point: 207.2±21.9 °C
- Vapor Pressure: Extremely low at room temperature (1.8×10?? mmHg)
- Hygroscopy: Non-hygroscopic; prone to oxidation under warm, open air
- Storage requirement: Sealed, light-proof, -20°C low-temperature storage recommended
Chemical Properties
- Core structure: Resorcinol benzene ring linked with pentyl alkyl and monoterpene diene side chain, two phenolic hydroxyl groups
- Phenolic hydroxyl activity: Weak acidity (pKa=9.71), can form salts with alkali metals; undergoes esterification, etherification reactions
- Thermal stability: Stable below 140°C; thermal degradation above 150°C, generates terpene decomposition impurities
- Photostability: Sensitive to UV light; long-term illumination causes oxidation, yellow discoloration and potency loss
- Acid-base tolerance: Stable in neutral/weak acid environments; strong alkali heating triggers side-chain double bond isomerization; concentrated strong acid promotes dehydration
- Oxidation susceptibility: Easily oxidized by air oxygen when exposed; must add antioxidants for long-term preservation
- Receptor selectivity: Non-psychoactive cannabinoid, weak partial agonist of CB1/CB2 receptors, no euphoric effect
- Compatibility: Compatible with vegetable oils, medium-chain triglycerides, cosmetic solvents; incompatible with strong oxidants, concentrated strong alkali
3. Main Application Fields
1. Pharmaceutical Research Raw Material (Core Application)
- Neuroprotective research compound: Studied for relieving inflammatory pain, anxiety, migraine, neurodegenerative disease auxiliary treatment
- Anti-inflammatory & antibacterial lead compound: Inhibits skin and mucosal pathogenic bacteria, regulates inflammatory cytokine release
- Ocular disease research reagent: Raw material for glaucoma intraocular pressure regulation experimental preparations
- Anti-tumor screening tool: Used for in vitro cell experiments of colon, skin tumor cell proliferation inhibition research
2. Cosmetic Skin Care Raw Material
- Skin anti-inflammatory soothing additive: Relieves sensitive skin redness, itching, improves eczema and dermatitis discomfort
- Antioxidant anti-aging ingredient: Scavenges free radicals, reduces UV-induced skin photoaging
- Sebum regulating agent: Added to facial essence, cream, facial mask, acne care products to balance oily skin secretion
3. Natural Plant Extract Standard Reference
High-purity HPLC standard substance for cannabis plant cannabinoid qualitative & quantitative detection; quality control standard for industrial hemp extract production process
4. Functional Food & Dietary Supplement Raw Material
Food-grade CBG monomer for health care oral oil, soft capsule raw materials; auxiliary ingredient for sleep regulation, immune balance functional supplements
5. Organic Synthesis Intermediate
Precursor for synthetic novel cannabinoid derivatives; structural modification raw material for developing new non-psychoactive therapeutic small molecules
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 25654-31-3 |
| Molecular Formula | C21H32O2 |
| Molecular Weight | 316.48 |
| Appearance | White to off-white crystalline powder |
| HPLC Purity | Research Grade ≥98.0%; Cosmetic/Food Grade ≥99.0% |
| Melting Range | 49.0 ~ 50.0 °C |
| Moisture Content (KF) | ≤0.10% |
| Single Unknown Related Impurity | ≤0.10% |
| Total Related Impurities | ≤0.80% |
| Heavy Metals (Pb) | ≤10 ppm (Cosmetic Grade ≤2 ppm) |
| Arsenic (As) | ≤2 ppm |
| Residual Organic Solvents | Meet ICH Q3C limit standards |
| Bulk Package | 1g/5g nitrogen-filled amber glass bottle, 1kg aluminum foil vacuum bag |
| Storage Condition | Hermetic nitrogen-filled light-proof warehouse at -20°C; isolate air, high temperature and ultraviolet light |
| Transportation Rule | Low-temperature light-proof sealed transport, avoid high temperature exposure |
| Shelf Life | 24 months under intact nitrogen-sealed low-temperature storage |
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