Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: Anastrozole
Alias: α,α,α',α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
CAS No.: 120511-73-1
Molecular Formula: C17H19N5
Molecular Weight: 293.37
2. Physical & Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder
- Odor: Odorless
- Solubility: Slightly soluble in water; soluble in methanol, ethanol, acetonitrile, DMSO, dichloromethane; sparingly soluble in ethyl acetate; insoluble in alkane solvents
- Melting Point: 81–83 °C
- Density (25℃): 1.16 g/cm3
- Predicted Boiling Point: 469.7±45.0 °C (760 mmHg)
- Flash Point: 237.9±28.7 °C
- Hygroscopy: Non-hygroscopic, stable under normal humidity
- Optical property: No chiral carbon, achiral compound without optical rotation
- Storage condition: Room temperature sealed away from strong light
Chemical Properties
- Molecular structure: Contains 1,2,4-triazole ring, two cyano groups and tetramethylbenzene skeleton, core aromatase inhibiting pharmacophore
- Triazole ring characteristic: Weakly alkaline nitrogen heterocycle, can form weak complexes with metal ions
- Cyano group stability: Stable under neutral, weak acid and weak alkaline conditions; severe hydrolysis only under strong acid/strong alkali heating
- Thermal stability: Stable below 75℃; above melting point slow decomposition, cyano group hydrolysis generates amide related impurities
- pH stability: Excellent stability in pH 3–9 aqueous system; long-term boiling in concentrated acid produces triazole ring cleavage impurities
- Photostability: Avoid long-term UV irradiation; light exposure produces trace unknown degradation impurities
- Oxidation resistance: Not easily oxidized by air at room temperature; incompatible with strong oxidizing agents
- Compatibility: Compatible with common pharmaceutical solvents and oral solid excipients; incompatible with concentrated mineral acid, strong alkali, peroxide oxidants
3. Main Application Fields
1. Anti-breast Cancer API (Core Application)
Highly selective non-steroidal aromatase inhibitor oral drug. Blocks aromatase activity to suppress peripheral estrogen synthesis, lowers estrogen level in patients.
- Indications: First-line treatment for postmenopausal women with hormone receptor positive early & advanced breast cancer; adjuvant therapy after breast cancer surgery to reduce recurrence risk
- Advantages: High selectivity, no obvious androgen side effects, convenient once-daily oral administration
2. Pharmaceutical Raw Material & Intermediate
- Bulk drug raw material for anastrozole oral tablets finished preparations
- Lead compound for developing new aromatase inhibitor anti-tumor drugs, structural modification and screening precursor
3. Biochemical Research Reagent
- Specific aromatase inhibitor probe for in vitro enzyme activity testing, estrogen metabolism research
- Cell experimental compound for studying hormone-dependent tumor cell proliferation mechanism
4. Pharmaceutical Reference Standard
High-purity reference substance for HPLC impurity inspection, finished product quality control and pharmaceutical production process verification
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 120511-73-1 |
| Molecular Formula | C17H19N5 |
| Molecular Weight | 293.37 |
| Appearance | White to off-white crystalline powder |
| HPLC Purity | Pharma Grade ≥99.0%; USP/EP Grade 98.0%–102.0% |
| Melting Range | 81.0 ~ 83.0 °C |
| Moisture Content (KF) | ≤0.20% |
| Single Unknown Related Impurity | ≤0.10% |
| Total Related Impurities | ≤0.50% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Residual Organic Solvents | Comply with ICH Q3C limit requirements |
| Bulk Package | 1kg / 5kg nitrogen-filled vacuum aluminum foil bag |
| Storage Condition | Hermetic light-proof dry warehouse ≤25℃; isolate strong light, high temperature and acid/oxidant gas |
| Transportation Rule | General pharmaceutical raw material, light-proof sealed moisture-proof packaging |
| Shelf Life | 24 months under intact sealed packaging |
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