Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: Creatine monohydrate
Alias: Methylguanidinoacetic acid monohydrate
CAS No.: 6020-87-7
Molecular Formula: C4H11N3O3
Molecular Weight: 149.15
2. Physical & Chemical Properties
Physical Properties
- Appearance: White crystalline powder or fine needle crystal
- Odor: Odorless, slightly bitter taste
- Solubility: Slightly soluble in cold water, soluble in hot water; insoluble in ethanol, acetone, ether and lipid solvents
- Melting Point: Decomposes at 212–216 °C without clear melting point
- Density (25℃): 1.33 g/cm3
- pH value (1% aqueous suspension): 6.5–8.0, weakly neutral
- Hygroscopy: Slightly hygroscopic under high humidity environment
- Crystal characteristic: Stable monohydrate crystal form; loses crystal water above 100℃ to form anhydrous creatine
- Particle feature: Uniform fine powder after crushing, good fluidity for raw material mixing
- UV absorption: No characteristic absorption peak in ultraviolet region
Chemical Properties
- Molecular structure: Contains guanidine alkaline group and carboxyl group, amphoteric compound with weak acid and weak base dual properties
- Crystal water property: Bound crystal water can be removed by heating at 100–110℃, anhydrous creatine easily absorbs water to recover monohydrate
- Cyclization reaction: Long-term heating in aqueous solution cyclizes to form creatinine, the main degradation impurity
- Salt-forming property: Guanidine group can combine with inorganic acids to form creatine salts (creatine hydrochloride, creatine citrate etc.)
- Thermal stability: Stable below 90℃; above 100℃ dehydration occurs; above 200℃ cyclization and decomposition generate creatinine and ammonia
- Acid-base stability: Stable under neutral and weak acid conditions; strong acid/strong alkali heating accelerates cyclization to creatinine
- Photostability: Stable under normal light; long-term strong ultraviolet irradiation slightly accelerates degradation
- Compatibility: Compatible with protein powder, amino acids, carbohydrates, food additives; incompatible with strong oxidants, concentrated strong acid and strong alkali
3. Main Application Fields
1. Sports Nutrition Supplement (Core Application)
The most mainstream sports nutritional raw material. Supplement intracellular phosphocreatine reserves, rapidly supply ATP energy for short-term high-intensity explosive movements, improve muscle strength, endurance and explosive power, accelerate muscle recovery after training. Widely added to muscle gain powder, pre-workout supplements, fitness oral powder, sports drinks.
2. Food & Nutritional Fortifier
Nutritional additive for functional food, dairy products, cereal meal replacement powder; auxiliary energy supplement for people with low physical activity, sub-health population, adolescents.
3. Pharmaceutical Industry
- Raw material for nutritional injection, enteral nutrition preparations, used for postoperative physical recovery, chronic fatigue auxiliary nutrition supply
- Intermediate for brain energy metabolism regulating drugs, research raw material for anti-fatigue oral preparations
- Standard reference substance for creatinine detection in clinical biochemical testing
4. Feed Additive
Feed-grade creatine monohydrate added to livestock, poultry and aquaculture feed; improve animal muscle growth rate, meat yield, reduce fat deposition, enhance animal anti-stress ability.
5. Biochemical Laboratory Reagent
- Standard sample for HPLC detection of creatine and creatinine in biological samples
- Cell culture medium additive for muscle cell metabolism research, energy metabolism experimental reagent
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 6020-87-7 |
| Molecular Formula | C4H11N3O3 |
| Molecular Weight | 149.15 |
| Appearance | White fine crystalline powder |
| HPLC Purity | Sports Grade ≥99.0%; Pharma/Food Grade ≥99.5% |
| Decomposition Range | 212.0 ~ 216.0 °C |
| Moisture (Crystal Water) | 11.8–12.4% |
| Creatinine Impurity | ≤0.10% |
| Moisture Free Water | ≤0.20% |
| Heavy Metals (Pb) | ≤10 ppm (Food/Pharma ≤2 ppm) |
| Arsenic (As) | ≤2 ppm |
| Residue on Ignition | ≤0.10% |
| Bulk Package | 25kg PE lined woven bag / aluminum foil vacuum bag |
| Storage Condition | Hermetic cool dry warehouse ≤25℃; isolate humid air and high temperature heat source |
| Transportation Rule | Ordinary nutritional raw material solid, moisture-proof sealed packaging |
| Shelf Life | 24 months under intact sealed packaging |
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