Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: 1-Tetralone
Alias: α-Tetralone, 3,4-Dihydro-1(2H)-naphthalenone
CAS No.: 529-34-0
Molecular Formula: C10H10O
Molecular Weight: 146.19
2. Physical & Chemical Properties
Physical Properties
- Appearance: Colorless to pale yellow transparent oily liquid
- Odor: Mild aromatic ketone odor
- Solubility: Insoluble in water; miscible with ethanol, methanol, toluene, xylene, dichloromethane, ethyl acetate
- Density (20℃): 1.098–1.102 g/cm3
- Melting Point: 7–8 ℃
- Boiling Point: 255–257 ℃
- Refractive Index nD2?: 1.560–1.563
- Closed-cup Flash Point: 110 ℃
- Freezing property: Solidifies at temperature below 7℃
- Hygroscopy: Non-hygroscopic
Chemical Properties
- Molecular structure: Fused ring structure of benzene ring and cyclohexanone ring, aromatic conjugated ketone
- Carbonyl reactivity: α-active hydrogen beside carbonyl can undergo aldol condensation, halogenation, enolization reaction
- Reduction performance: Reduced to 1-tetralol by sodium borohydride; deep hydrogenation yields tetralin
- Aromatic ring substitution: Benzene ring undergoes electrophilic substitution such as nitration, sulfonation, Friedel-Crafts reaction
- Thermal stability: Stable below 230℃; long-term heating above boiling point generates tarry polymerization impurities
- Photostability: Avoid long-term UV irradiation; light exposure deepens color and produces unknown oxidation impurities
- Acid-base stability: Stable under neutral and weak acid conditions; concentrated strong alkali heating causes side-chain cleavage
- Compatibility: Compatible with common organic solvents and resin monomers; incompatible with strong oxidants, concentrated strong alkali
3. Main Application Fields
1. Pharmaceutical Synthetic Intermediate (Core Application)
Key raw material for synthesizing tetralin-series APIs, including antidepressants, anti-inflammatory drugs, cardiovascular drugs, and selective serotonin receptor modulators. Used to construct chiral tetralin skeleton via asymmetric reduction and chiral resolution.
2. Fragrance & Aroma Intermediate
Precursor for synthetic musk, woody aroma spices; used to prepare tetralin musk derivatives with lasting woody fragrance.
3. Organic Electronic Material Intermediate
Synthetic building block for conjugated luminescent materials, organic photoelectric semiconductors; raw material for OLED hole transport layer monomers.
4. Pesticide & Fungicide Intermediate
Skeleton precursor for new high-efficiency bactericides and insect growth regulators; used to synthesize heterocyclic pesticide active ingredients.
5. Laboratory Organic Synthesis Reagent
Standard cyclic aromatic ketone substrate for organic methodology research, asymmetric catalysis, and chiral catalyst screening experiments.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 529-34-0 |
| Molecular Formula | C10H10O |
| Molecular Weight | 146.19 |
| Appearance | Colorless to pale yellow oily liquid |
| GC Purity | Synthetic Grade ≥98.0%; Pharma Grade ≥99.0% |
| Boiling Range | 255.0 ~ 257.0 ℃ |
| Density (20℃) | 1.098–1.102 g/cm3 |
| Refractive Index nD2? | 1.560–1.563 |
| Moisture Content (KF) | ≤0.10% |
| Chroma (Pt-Co) | ≤50 |
| Heavy Metals (Pb) | ≤10 ppm |
| Bulk Package | 25L plastic drum / 200L iron drum |
| Storage Condition | Hermetic light-proof cool dry warehouse ≤25℃; isolate strong light, high temperature and oxidants |
| Transportation Rule | General organic chemical liquid, sealed anti-leak packaging |
| Shelf Life | 24 months under intact sealed packaging |
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