Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: Mecobalamin
Alias: Methylcobalamin, Coα-(α-5,6-dimethylbenzimidazolyl)-Coβ-methylcobamide
CAS No.: 13422-55-4
Molecular Formula: C63H91CoN13O14P
Molecular Weight: 1344.38
2. Physical & Chemical Properties
Physical Properties
- Appearance: Dark red crystalline powder
- Odor: Odorless, tasteless
- Solubility: Soluble in water and methanol; slightly soluble in ethanol; insoluble in acetone, ether, benzene and chloroform
- Hygroscopy: Slightly hygroscopic under high humidity
- Optical property: Optically active substance with specific optical rotation
- UV absorption: Characteristic absorption peaks at 266 nm, 342 nm and 522 nm
- Thermal property: Decomposes at high temperature without obvious melting point
Chemical Properties
- Molecular structure: Active coenzyme form of vitamin B12, central cobalt atom combined with methyl group, contains corrin ring, phosphate group and dimethylbenzimidazole side chain
- Photolysis characteristic: Extremely sensitive to light, UV irradiation quickly decomposes and loses biological activity, must be stored in light-proof packaging
- Redox property: Methyl group connected to cobalt is active; easy to transfer methyl group to participate in human one-carbon metabolism
- Acid-base stability: Stable in neutral and weak acidic environment; strong acid or strong alkali will destroy corrin ring structure and deactivate
- Metal ion reaction: Heavy metal ions such as copper, iron can accelerate its oxidative decomposition
- Thermal stability: Heating above 100℃ leads to rapid degradation and activity decline
- Compatibility: Compatible with other B vitamins under light-proof conditions; incompatible with oxidants, strong acid, strong alkali, heavy metal salts
3. Main Application Fields
1. Pharmaceutical API (Core Application)
- Oral mecobalamin tablets, capsules, injections: Treat megaloblastic anemia caused by vitamin B12 deficiency
- Peripheral nerve repair drug: Improve numbness, tingling, pain of peripheral neuritis, diabetic neuropathy
- Auxiliary treatment for hyperhomocysteinemia, reduce cardiovascular disease risk
2. Nutritional Health Products
Functional food raw material for nerve care, blood tonic health care products; nutritional fortifier for middle-aged and elderly, pregnant women and people with poor absorption of vitamin B12
3. Feed Additive
Feed-grade mecobalamin for livestock, poultry and aquaculture; promote animal hematopoiesis and nerve development, improve breeding survival rate
4. Biochemical Research Reagent
Standard reference substance for HPLC detection of vitamin B12 active form; cell culture medium additive for nerve cell metabolism research
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 13422-55-4 |
| Molecular Formula | C63H91CoN13O14P |
| Molecular Weight | 1344.38 |
| Appearance | Dark red crystalline powder |
| HPLC Purity | Pharma Grade ≥98.0%; USP/EP Grade 97.0%–102.0% |
| Moisture Content (KF) | ≤8.0% |
| Residue on Ignition | ≤0.20% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Related Substances | Total impurities ≤1.0% |
| Bulk Package | Aluminum foil vacuum bag, amber light-proof plastic bottle |
| Storage Condition | Hermetic light-proof low-temperature warehouse 2–8℃; isolate light, high temperature, oxidants and metal raw materials |
| Transportation Rule | Light-proof sealed moisture-proof packaging, avoid sunlight exposure and high temperature transportation environment |
| Shelf Life | 24 months under intact sealed packaging |
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