Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: Tris Base
Alias: Tromethamine, Tris(hydroxymethyl)aminomethane
CAS No.: 77-86-1
Molecular Formula: C4H11NO3
Molecular Weight: 121.14
2. Physical & Chemical Properties
Physical Properties
- Appearance: White crystalline powder
- Odor: Odorless, slightly bitter taste
- Solubility: Easily soluble in water, methanol; slightly soluble in ethanol; insoluble in acetone, ether, benzene
- Melting Point: 168–172 ℃
- pH Value (0.1mol/L aqueous solution): 10.0–10.8, weak alkalinity
- Hygroscopy: Slightly hygroscopic under high humidity
- Crystal feature: Uniform monoclinic crystal, good fluidity
- Buffer performance: Excellent buffer capacity in pH 7.0–9.0 range
Chemical Properties
- Molecular structure: Contains one amino group and three hydroxymethyl groups, polyhydroxy organic amine
- Acid-base reaction: Amino group neutralizes acid to form Tris hydrochloride buffer salt
- Hydroxyl reactivity: Hydroxyl groups can undergo esterification reaction with carboxylic acid
- Thermal stability: Stable below 150℃; above melting point sublimates without obvious decomposition
- Photostability: Stable under light, no discoloration for long-term storage
- Metal chelation: Weak chelating ability with heavy metal ions
- Compatibility: Compatible with most biological reagents, amino acids, enzymes; incompatible with strong oxidants, heavy metal salts
3. Main Application Fields
1. Biochemical Laboratory Buffer (Core Application)
Widely used buffer raw material for protein electrophoresis, nucleic acid extraction, cell culture, enzyme reaction system; configure neutral/weak alkaline biological buffer solution.
2. Pharmaceutical Raw Material
- Raw material for amino acid infusion, blood dialysis solution, pharmaceutical pH regulator
- Excipient for eye drops, injection liquid to stabilize solution pH value
3. Cosmetic Raw Material
pH adjuster for facial mask, essence, emulsion; mild weak alkali, reduce skin irritation compared with inorganic alkali.
4. Industrial Water Treatment & Electronic Auxiliary
pH regulator for ultra-pure water, circuit board cleaning fluid, biological fermentation liquid pH control agent.
5. Organic Synthesis Intermediate
Raw material for synthesizing polyurethane crosslinkers, surfactant intermediates.
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 77-86-1 |
| Molecular Formula | C4H11NO3 |
| Molecular Weight | 121.14 |
| Appearance | White crystalline powder |
| HPLC Purity | Biochemical Grade ≥99.0%; Pharma Grade ≥99.5% |
| Melting Range | 168.0 ~ 172.0 ℃ |
| Moisture Content (KF) | ≤0.10% |
| Residue on Ignition | ≤0.05% |
| Heavy Metals (Pb) | ≤5 ppm |
| Arsenic (As) | ≤1 ppm |
| pH (0.1M water solution) | 10.0–10.8 |
| Bulk Package | 25kg PE lined fiber drum / aluminum foil vacuum bag |
| Storage Condition | Hermetic cool dry warehouse ≤25℃; isolate humid air and oxidants |
| Transportation Rule | Organic amine solid, moisture-proof sealed packaging |
| Shelf Life | 24 months under intact sealed packaging |
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