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1. Basic Info
Name: BPC 157
Alias: Pentadecapeptide BPC 157, Body Protection Compound 157
CAS No.: 137525-51-0
Amino acid sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Molecular Formula: C62H98N16O22
Molecular Weight: 1419.54
2. Physical & Chemical Properties
Physical Properties
- Appearance: White to off-white lyophilized crystalline powder, odorless
- Solubility: Freely soluble in pure water (≥100 mg/mL); soluble in DMSO; slightly soluble in methanol; insoluble in alkanes, ether, ethyl acetate
- Melting point: >232 ℃ (decomposes when heated)
- Density (predicted): 1.366 g/cm3
- Hygroscopy: Strongly hygroscopic, absorbs moisture rapidly in humid air
- pH of aqueous solution: Weakly acidic, stable in pH 2–9 environment
- Optical property: Linear uncyclized peptide, no disulfide bonds, no oxidation-induced conformational failure
- Thermal stability: Unique proline-rich structure resists degradation by gastric acid, pepsin and trypsin; maintains biological activity under mild heating
Chemical Properties
- Structural feature: 15 linear amino acids, contains continuous tri-proline rigid segment, forms polyproline II helix, high protease resistance
- Amphipathic characteristic: Contains acidic carboxyl groups (Glu, Asp) and basic amino group (Lys), carries mixed charges in water solution
- Hydrolysis stability: Resists gastrointestinal enzymatic hydrolysis; oral administration can maintain intact peptide structure without carrier coating
- Salt formation: Can form acetate / trifluoroacetate salts during HPLC purification, common commercial form is BPC 157 acetate
- Photodegradation: Long-term UV exposure accelerates impurity generation and activity attenuation; must be stored away from light
- Compatibility: Compatible with aqueous buffer systems; incompatible with strong oxidants, heavy metal ions, high-concentration strong alkali
3. Main Application Fields
Important Regulatory Note
This peptide is only permitted for preclinical laboratory research use in China; there is no officially approved pharmaceutical product for human injection/oral administration. Unauthorized preparation, sales and human self-administration violate drug supervision regulations and carry health risks.
1. Gastrointestinal Injury Research (Core Research Direction)
- Preclinical study on gastric ulcer, duodenal ulcer, inflammatory bowel disease; study gastric mucosal cytoprotective, anti-inflammatory and mucosal repair mechanisms
- Animal model experiment for intestinal fistula, gastrointestinal perforation repair
2. Tissue Regeneration & Musculoskeletal Research
- Tendon, ligament, bone fracture, muscle injury repair model research; promotes angiogenesis and fibroblast proliferation
- Cartilage damage, joint inflammation preclinical pharmacodynamic evaluation
3. Organ & Vascular Injury Research
- Cardiovascular injury, myocardial ischemia, vascular endothelial damage repair experiment
- Liver/kidney acute injury protection, anti-fibrosis mechanism research
4. Nervous System & Inflammation Research
- Peripheral nerve injury, brain trauma neuroprotective study
- Systemic inflammatory response, oxidative stress damage model reagent
5. Biochemical Laboratory Standard Reference
- HPLC detection standard substance for peptide content quantitative analysis
- Cell culture medium additive for in vitro cell injury repair experiments
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 137525-51-0 |
| Molecular Formula | C62H98N16O22 |
| Molecular Weight | 1419.54 |
| Appearance | White lyophilized powder |
| HPLC Purity | Research Grade ≥98.0%; Premium Lab Grade ≥99.0% |
| Single Unknown Impurity | ≤1.0% |
| Total Impurities | ≤2.0% |
| Moisture Content | ≤10.0% |
| Acetate Salt Residue (acetate form) | 5.0%–12.0% |
| Heavy Metals (Pb) | ≤10 ppm |
| Storage Condition | Hermetic vacuum, light-proof, freezer storage at -20℃; avoid repeated freeze-thaw cycles; aqueous solution cannot be stored long-term |
| Transportation | Ice bag low-temperature sealed packaging, moisture-proof |
| Shelf Life | 24 months under intact vacuum freeze-dried packaging at -20℃ |
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