Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: Temocillin Disodium
Alias: Temocillin, BRL 17421, Negaban
CAS No.: 61545-06-0
Molecular Formula: C16H16N2O7S2·2Na
Molecular Weight: 458.42
2. Physical & Chemical Properties
Physical Properties
- Appearance: Off-white to pale yellow crystalline powder, odorless
- Solubility: Highly soluble in water (250 mg/mL, ultrasonic assist for full dissolution); slightly soluble in methanol; insoluble in acetone, ether, alkane solvents
- Hygroscopy: Strongly hygroscopic, absorbs moisture rapidly under humid air
- Optical characteristic: Multiple chiral carbon centers, optically active penicillin derivative
- Aqueous solution pH: Weakly alkaline; reconstituted injection liquid stable for 24 h at 25℃ in 0.9% NaCl / 5% glucose infusion fluid
- Thermal property: No distinct melting point; decomposes gradually above 120℃
Chemical Properties
- Core structure: 6-α-methoxy semisynthetic penicillin, β-lactam ring with steric hindrance, resistant to most common β-lactamases
- Hydrolysis degradation
- Strong acid environment: β-lactam ring hydrolyzes to form methoxypenillic acid
- Strong alkali / β-lactamase: Hydrolyze to methoxypenicilloic acid and epimer impurities
- Salt characteristic: Disodium salt form, two carboxyl groups neutralized with sodium ions, improves water solubility for injection administration
- Photostability: UV/strong light accelerates oxidation, solution turns yellow with activity loss; must be stored light-proof
- Compatibility: Compatible with neutral infusion buffer; incompatible with strong oxidants, heavy metal salts, high-concentration strong acid
- Antibacterial mechanism: Bind to PBP3 penicillin-binding protein, block peptidoglycan synthesis, induce gram-negative bacterial lysis
3. Main Application Fields
1. Clinical Pharmaceutical API (Core Application)
Prescription injectable antibiotic, narrow-spectrum anti-Gram-negative penicillin, effective against ESBL-producing multi-resistant enterobacteria
- Indications: Urinary tract infection, septicemia, lower respiratory tract infection, abdominal cavity, biliary tract, postoperative wound infection caused by sensitive bacteria (E.coli, Klebsiella, Proteus, Salmonella, Haemophilus influenzae)
- Administration: Intramuscular injection / slow intravenous injection, injection powder specifications: 1g, 2g
- Advantage: Alternative to carbapenems for ESBL gram-negative infection with lower side effects
2. Microbiological Laboratory Research Reagent
- Antibiotic screening standard for drug-resistance bacteria culture; prepare selective medium for ESBL strain identification
- HPLC reference standard for quantitative detection of β-lactam antibiotics in biological samples (serum, urine)
3. Pharmacodynamic & Mechanism Research Material
In vitro cell / animal model raw material: Study β-lactamase resistance mechanism, penicillin binding protein interaction, bacterial cell wall metabolism research
4. Quality Control Reference Substance
Used for pharmaceutical factory finished drug inspection, impurity spectrum verification of penicillin injection preparations
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 61545-06-0 |
| Molecular Formula | C16H16N2O7S2·2Na |
| Molecular Weight | 458.42 |
| Appearance | Off-white to pale yellow crystalline powder |
| HPLC Purity | Pharma Grade ≥98.0%; Reference Standard ≥99.0% |
| Single Maximum Impurity | ≤0.5% |
| Total Related Substances | ≤1.5% |
| Moisture Content (KF) | ≤5.0% |
| Heavy Metals (Pb) | ≤10 ppm |
| Loss on Ignition | 18.0%–20.0% (disodium salt) |
| Storage Condition | Hermetic vacuum, light-proof, -20℃ nitrogen-sealed storage; avoid repeated freeze-thaw; aqueous solution cannot long-term preserve |
| Transportation | Low-temperature insulated sealed packaging, moisture-proof, away from light |
| Shelf Life | 24 months under intact vacuum packaging at -20℃ |
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