Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: 3-Bromopyridine
Alias: 3-Pyridyl bromide, m-Bromopyridine
CAS No.: 626-55-1
Molecular Formula: C5H4BrN
Molecular Weight: 157.99
2. Physical & Chemical Properties
Physical Properties
- Appearance: Colorless to pale yellow transparent liquid
- Odor: Pungent pyridine-like irritating odor
- Solubility: Slightly soluble in water; miscible with ethanol, methanol, acetone, dichloromethane, toluene, ether
- Melting Point: 2.5–3.0 ℃
- Boiling Point: 173–174 ℃
- Density (20℃): 1.640 g/cm3
- Refractive Index nD2?: 1.569–1.572
- Hygroscopy: Absorbs trace water in air; long-term light exposure turns dark brown
Chemical Properties
- Molecular structure: Pyridine ring substituted with bromine at meta-position (3-site)
- Aromatic halogen reactivity: Undergoes Suzuki, Heck, Sonogashira, Buchwald cross-coupling reactions with palladium catalyst
- Weak alkalinity: Ring nitrogen combines with inorganic acids to form hydrobromide salts
- Metal lithiation: React with n-BuLi to generate 3-pyridyllithium for further functionalization
- Nucleophilic substitution: Bromine can be replaced by amine, cyano, hydroxyl, alkoxy groups
- Photodegradation: UV/light triggers dehalogenation and polymerization; must store light-proof
- Thermal stability: Stable at normal distillation temperature; high temperature above 220℃ releases bromide decomposition products
- Compatibility: Compatible with anhydrous organic solvents; incompatible with strong oxidants, strong alkali, active metals (Na, K)
3. Main Application Fields
1. Pharmaceutical Intermediate (Core Application)
- Building block for synthesizing nicotinamide derivatives, anti-inflammatory, anti-tumor, anti-neuropathic drugs
- Pyridine core skeleton for CNS targeted APIs, JAK/kinase inhibitor intermediates
2. Agrochemical Intermediate
Raw material for high-efficiency pyridine fungicides, insecticides, herbicides; construct heterocyclic pesticide pharmacophore
3. Organic Synthetic Ligand & Material Intermediate
- Precursor for 3-pyridyl functional bipyridine, terpyridine coordination ligands
- Raw material for organic optoelectronic materials, OLED luminescent layer intermediates
4. Cross-Coupling Reaction Standard Substrate
Laboratory synthesis reagent for developing palladium catalytic coupling process, pharmaceutical lab scale-up synthesis
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 626-55-1 |
| Molecular Formula | C5H4BrN |
| Molecular Weight | 157.99 |
| Appearance | Colorless to pale yellow liquid |
| GC Purity | Industrial Grade ≥98.0%; Pharma Intermediate Grade ≥99.0% |
| Moisture Content | ≤0.10% |
| Residual Bromide Impurity | ≤0.20% |
| Heavy Metals (Pb) | ≤10 ppm |
| Bulk Package | 25L/200L amber plastic-lined iron drum |
| Storage Condition | Hermetic nitrogen-filled light-proof warehouse ≤25℃; isolate light, water, alkaline substances |
| Transportation Rule | Irritant halogenated heterocyclic liquid, sealed anti-leakage packaging |
| Shelf Life | 12 months under intact nitrogen-sealed packaging |
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