Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: Betamethasone
Alias: 9α-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione
CAS No.: 378-44-9
Molecular Formula: C22H29FO5
Molecular Weight: 392.46
2. Physical & Chemical Properties
Physical Properties
- Appearance: White or off-white crystalline powder, odorless
- Solubility: Practically insoluble in water; slightly soluble in ethanol, methanol; soluble in acetone, chloroform, DMSO; sparingly soluble in ether
- Melting Point: 236–244 ℃ (decomposes during melting)
- Specific Optical Rotation [α]?2?: +108° ~ +116° (c=1, dioxane)
- Hygroscopy: Non-hygroscopic under normal ambient humidity
- Crystal morphology: Fine needle crystal after recrystallization from methanol-water mixed solvent
- UV characteristic: Characteristic maximum absorption at 240 nm in ethanol solution
Chemical Properties
- Structural feature: Synthetic fluorinated glucocorticoid steroid, contains fluorine at C9α, methyl at C16β, conjugated diene in A ring, multiple hydroxyl and ketone functional groups
- Steroid skeleton reactivity: 17α,21-dihydroxyketone side chain can form ester derivatives (betamethasone dipropionate, valerate) for better lipophilicity and transdermal effect
- Fluorine substitution effect: C9-F significantly enhances anti-inflammatory potency, reduces sodium retention side effects compared with cortisol
- Acid-base stability: Stable in neutral and weak acid environment; easily dehydrated and degraded under strong acid heating; strong alkali causes side chain cleavage
- Photodegradation: Long-term strong UV irradiation triggers double bond isomerization and impurity generation, must be stored away from light
- Thermal stability: Stable below 180 ℃; carbonization decomposition above melting point
- Compatibility: Compatible with neutral pharmaceutical auxiliary materials, vegetable oil matrix; incompatible with strong oxidants, concentrated strong acid/alkali, heavy metal salts
3. Main Application Fields
1. Pharmaceutical API (Core Application, Prescription Drug Only)
- Anti-inflammatory glucocorticoid raw material, stronger anti-inflammatory, anti-allergy, anti-proliferative activity than dexamethasone
- Oral tablets, injection formulations for systemic treatment: severe allergic diseases, autoimmune diseases, rheumatoid arthritis, dermatomyositis, asthma exacerbation
- Topical ointment, cream, lotion raw material: treat eczema, contact dermatitis, psoriasis, pruritus, lichen planus
- Eye/ear drop preparations for inflammatory ophthalmic and otologic diseases
- Compound preparations combined with antibiotics for inflammatory skin lesions complicated by infection
2. Preclinical Pharmacological Research Reagent
- Positive control drug for anti-inflammatory, immunosuppressive cell & animal model experiments
- Research material for glucocorticoid receptor binding mechanism, steroid drug metabolism study
3. Pharmaceutical Standard Reference
HPLC reference standard for content determination and impurity inspection of betamethasone raw materials and finished preparations
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 378-44-9 |
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.46 |
| Appearance | White crystalline powder |
| HPLC Purity | Pharma Grade ≥98.5%; Reference Standard ≥99.5% |
| Single Maximum Impurity | ≤0.5% |
| Total Related Substances | ≤1.5% |
| Moisture Content (KF) | ≤0.50% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Bulk Package | Light-proof aluminum foil vacuum bag, amber sealed glass bottle |
| Storage Condition | Hermetic, light-proof, cool dry warehouse ≤25℃; avoid high temperature and strong light irradiation |
| Transportation Rule | Steroid pharmaceutical raw material, sealed light-proof moisture-proof packaging |
| Shelf Life | 24 months under intact vacuum packaging |
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