Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: Dexamethasone
Alias: 9α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
CAS No.: 50-02-2
Molecular Formula: C22H29FO5
Molecular Weight: 392.46
2. Physical & Chemical Properties
Physical Properties
- Appearance: White or off-white crystalline powder, odorless
- Solubility: Insoluble in water; slightly soluble in ethanol, methanol; soluble in acetone, chloroform, DMSO; sparingly soluble in ether
- Melting Point: 262–264 ℃ (decomposes on melting)
- Specific rotation [α]?2?: +72° ~ +80° (dioxane solvent)
- UV absorption: Maximum absorption at 240 nm in ethanol
- Hygroscopy: Non-hygroscopic under normal humidity
- Crystal form: Fine needle crystals after recrystallization from methanol-water
Chemical Properties
- Skeleton structure: Synthetic fluorinated glucocorticoid, C9α fluorine, C16α methyl group, conjugated diene on steroid A ring
- Esterification activity: 17,21 dihydroxy side chain can react with carboxylic acids to form dexamethasone sodium phosphate, acetate, palmitate for injection/topical use
- Pharmacological structural advantage: C9-F greatly boosts anti-inflammatory activity; C16 methyl eliminates water-sodium retention side effects
- Acid-base stability: Stable in neutral and weak acid environments; strong acid heating causes dehydration degradation; concentrated alkali breaks the 21-hydroxy ketone side chain
- Photostability: Sensitive to strong UV light, long-term illumination produces isomer impurities, requires light-proof storage
- Thermal stability: Stable below 180℃; carbonization decomposition above melting point
- Compatibility: Compatible with neutral pharmaceutical excipients, oily substrates; incompatible with strong oxidants, concentrated acid/alkali, heavy metal salts
3. Main Application Fields
1. Prescription Pharmaceutical API (Core Application)
- High-efficiency anti-inflammatory, anti-allergy, immunosuppressive glucocorticoid, potency far stronger than hydrocortisone
- Systemic formulations (tablets, injections): Treat severe anaphylaxis, autoimmune diseases, rheumatoid arthritis, bronchial asthma crisis, cerebral edema, malignant tumor adjuvant therapy
- External preparations (ointment, cream): Treat eczema, dermatitis, psoriasis, itchy skin disorders
- Ophthalmic, otologic drops for inflammatory mucosal lesions
- Compound formulations combined with antibiotics for infected inflammatory skin diseases
2. Pharmacology Laboratory Research Reagent
- Positive control drug for cell/animal anti-inflammatory, immunosuppression experiments
- Research material for glucocorticoid receptor binding, steroid metabolism pathway study
3. Pharmaceutical Quality Control Reference Standard
HPLC standard substance for content and related substance detection of dexamethasone raw materials and finished drugs
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 50-02-2 |
| Molecular Formula | C22H29FO5 |
| Molecular Weight | 392.46 |
| Appearance | White crystalline powder |
| HPLC Purity | Pharma Grade ≥98.5%; Reference Standard ≥99.5% |
| Single maximum impurity | ≤0.5% |
| Total related substances | ≤1.5% |
| Moisture (KF) | ≤0.50% |
| Residue on ignition | ≤0.10% |
| Heavy metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Packaging | Light-proof aluminum foil vacuum bag, amber sealed glass bottle |
| Storage | Hermetic, light-proof, cool dry warehouse ≤25℃; avoid high temperature and direct sunlight |
| Transportation | Steroid pharmaceutical raw material, sealed light-proof and moisture-proof package |
| Shelf life | 24 months under intact vacuum packaging |
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