Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: DL-Thioctic acid
Alias: DL-Lipoic acid, 6,8-Dithiooctanoic acid
CAS No.: 1077-28-7
Molecular Formula: C8H14O2S2
Molecular Weight: 206.32
2. Physical & Chemical Properties
Physical Properties
- Appearance: Yellow crystalline powder, slight sulfur odor
- Solubility: Insoluble in water; soluble in ethanol, methanol, chloroform, DMSO, vegetable oils; slightly soluble in hexane
- Melting Point: 58–62 ℃
- UV characteristic: Weak absorption in ultraviolet region
- Hygroscopy: Slightly hygroscopic under high humidity air
- Optical property: Racemic mixture, no optical rotation (differ from natural L-lipoic acid)
Chemical Properties
- Molecular structure: Contains a five-membered cyclic disulfide ring and terminal carboxyl group; exists as racemate of R-lipoic acid and S-lipoic acid
- Redox reversible: Disulfide ring can be reduced to two thiol groups (dihydrolipoic acid), powerful dual water-lipid soluble antioxidant
- Esterification reaction: Carboxyl group reacts with alcohols to form lipoate esters for cosmetic & pharmaceutical use
- Oxidation sensitivity: Long-term exposure to air/light triggers disulfide polymerization, color deepens to dark yellow
- Thermal stability: Stable below 70 ℃; above melting point easy to oxidize and volatilize
- Acid-base property: Weak organic acid, reacts with alkali metals to form soluble lipoate salts
- Compatibility: Compatible with vitamin C, vitamin E, plant oil carriers; incompatible with heavy metal ions, strong oxidants
3. Main Application Fields
1. Health Food Raw Material (Core Application)
- Universal antioxidant, eliminate free radicals, improve glucose metabolism auxiliary raw material
- Anti-aging, peripheral nerve protection health supplement raw material (racemic DL type lower cost than natural L-type)
- Compound antioxidant formula matched with VC, VE, glutathione
2. Pharmaceutical API & Auxiliary
- Raw material for oral drugs treating diabetic peripheral neuropathy
- Antioxidant stabilizer for injections, protect active ingredients from oxidative damage
3. Cosmetic Active Additive
- Anti-oxidation, anti-glycation, anti-photoaging raw material for essence, facial cream, mask
- Improve skin dullness, repair oxidative damaged skin barrier
4. Biochemical Laboratory Reagent
- Redox cofactor for cell metabolism, mitochondrial function research
- Standard reference for lipoic acid content HPLC detection
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 1077-28-7 |
| Molecular Formula | C8H14O2S2 |
| Molecular Weight | 206.32 |
| Appearance | Yellow crystalline powder |
| HPLC Purity | Food Grade ≥99.0%; Pharma Grade ≥99.5% |
| Moisture Content (KF) | ≤0.20% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Arsenic (As) | ≤2 ppm |
| Bulk Package | Nitrogen-sealed aluminum foil vacuum bag, amber glass bottle |
| Storage Condition | Hermetic nitrogen-filled, light-proof, cool dry warehouse ≤25℃; avoid air contact |
| Transportation Rule | Sulfur-containing antioxidant raw material, sealed light-proof moisture-proof packaging |
| Shelf Life | 24 months under intact nitrogen vacuum packaging |
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