Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: Dicyclohexylcarbodiimide
Alias: DCC, N,N'-Dicyclohexylcarbodiimide
CAS No.: 538-75-0
Molecular Formula: C13H22N2
Molecular Weight: 222.33
2. Physical & Chemical Properties
Physical Properties
- Appearance: White crystalline solid
- Odor: Pungent irritating odor
- Solubility: Insoluble in water; soluble in dichloromethane, chloroform, tetrahydrofuran, acetonitrile, toluene
- Melting Point: 34–36 ℃
- Boiling Point: 154–156 ℃ (12 mmHg)
- Density (20℃): 1.32 g/cm3
- Hygroscopy: Slightly hygroscopic, reacts with water slowly
- Corrosiveness: Irritates skin, eyes and respiratory tract severely
Chemical Properties
- Core structure: Contains N=C=N carbodiimide active functional group, high dehydration/condensation activity
- Dehydration condensation: Classic peptide coupling reagent, activates carboxylic acid to react with amine to form amide peptide bond
- Esterification promotion: Catalyzes condensation of carboxylic acid and alcohol to generate ester
- Reaction with water: Hydrolyzes slowly to form dicyclohexylurea (DCU) insoluble precipitate
- Acid neutralization: Reacts with carboxylic acid to form O-acylisourea active intermediate
- Thermal stability: Stable under normal temperature; decomposes above 200 ℃ to release toxic nitrogen-containing fragments
- Compatibility: Compatible with anhydrous aprotic solvents; strictly avoid water, alcohols, strong acids, strong oxidants
3. Main Application Fields
1. Peptide Synthesis Coupling Reagent (Core Application)
- Laboratory solid-phase & liquid-phase peptide synthesis dehydrating agent, widely used for amino acid condensation
- Synthetic raw material for polypeptide drugs, bioactive peptide monomers
2. Organic Synthetic Dehydration Agent
- Catalyze esterification, amidation, anhydride formation reaction
- Dehydration cyclization for heterocyclic pharmaceutical intermediates
3. Polymer Material Synthesis Auxiliary
- Condensation agent for polyamide, polyester high molecular polymer lab synthesis
- Crosslinking modifier for natural macromolecules such as protein and polysaccharide
4. Biochemical Research Reagent
Activation reagent for carboxyl groups of enzymes, protein modification labeling experiments
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 538-75-0 |
| Molecular Formula | C13H22N2 |
| Molecular Weight | 222.33 |
| Appearance | White crystal solid |
| GC Purity | Synthetic Grade ≥99.0%; Peptide Synthesis Grade ≥99.5% |
| Moisture Content | ≤0.10% |
| DCU Impurity | ≤0.30% |
| Heavy Metals (Pb) | ≤10 ppm |
| Bulk Package | Aluminum foil vacuum bag, amber sealed plastic bottle |
| Storage Condition | Hermetic anhydrous light-proof warehouse ≤25℃; isolate water, humid air, acidic substances |
| Transportation Rule | Irritant toxic organic solid, sealed moisture-proof packaging, avoid skin contact |
| Shelf Life | 24 months under intact anhydrous vacuum packaging |
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