Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: Nitrazolam
Alias: 1-Methyl-8-nitro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS No.: 28910-99-8
Molecular Formula: C17H13N5O2
Molecular Weight: 319.32
2. Physical & Chemical Properties
Physical Properties
- Appearance: Pale yellow crystalline powder, odorless
- Solubility: Insoluble in water; soluble in chloroform, dichloromethane, DMSO; slightly soluble in methanol, ethanol
- Melting Point: 214–217 ℃ (decomposes slightly)
- UV characteristic: Characteristic absorption peaks at 230 nm, 350 nm in methanol solution
- Hygroscopy: Non-hygroscopic under normal ambient humidity
- Crystal form: Fine needle crystal recrystallized from ethanol
Chemical Properties
- Molecular structure: Triazolobenzodiazepine psychoactive compound, contains nitro group, triazole ring and benzodiazepine fused ring
- Reduction characteristic: Aromatic nitro group can be reduced to amino group under reducing agent
- Photodegradation: Sensitive to ultraviolet light, long-term illumination generates degradation impurities
- Acid-base stability: Stable in neutral and weak acid environment; concentrated strong acid hydrolyzes triazole ring
- Thermal stability: Stable below 180 ℃; above melting point thermal decomposition produces toxic nitrogen-containing fragments
- Compatibility: Compatible with anhydrous halogenated solvents; avoid mixing with strong oxidants, strong reducing agents
3. Main Application Fields
1. Forensic Standard Reference Substance (Core Application)
- HPLC/GC-MS standard for drug testing, forensic toxicology detection of new psychoactive benzodiazepines
- Calibration sample for laboratory drug screening instruments
2. Pharmacological Research Reagent
- In vitro cell experiment reagent for studying benzodiazepine receptor binding activity
- Preclinical research tool for sedative, hypnotic and anxiolytic mechanism study
4. Organic Synthetic Intermediate
Laboratory raw material for synthesizing triazolobenzodiazepine derivative analogues
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 28910-99-8 |
| Molecular Formula | C17H13N5O2 |
| Molecular Weight | 319.32 |
| Appearance | Pale yellow crystalline powder |
| HPLC Purity | Reference Standard ≥99.5%; Research Grade ≥99.0% |
| Moisture Content (KF) | ≤0.20% |
| Residue on Ignition | ≤0.05% |
| Heavy Metals (Pb) | ≤10 ppm |
| Bulk Package | Nitrogen-sealed amber glass bottle, aluminum foil vacuum packaging |
| Storage Condition | Hermetic light-proof low-temperature warehouse ≤15℃; strictly avoid light and dampness |
| Transportation Rule | Controlled psychoactive reference substance, sealed light-proof anti-theft packaging |
| Shelf Life | 18 months under intact vacuum light-proof packaging |
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