Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Info
Name: N,N-Dimethylformamide dimethyl acetal
Alias: DMF-DMA, 1,1-Dimethoxy-N,N-dimethylethanamine
CAS No.: 4637-24-5
Molecular Formula: C5H13NO2
Molecular Weight: 119.16
2. Physical & Chemical Properties
Physical Properties
- Appearance: Colorless transparent low-viscosity liquid
- Odor: Mild amine characteristic odor
- Solubility: Miscible with methanol, ethanol, dichloromethane, THF, acetone; reacts with water, cannot be dissolved stably in aqueous system
- Melting Point: -85 ℃
- Boiling Point: 104–106 ℃
- Density (20℃): 0.890–0.895 g/cm3
- Refractive Index nD20: 1.395–1.398
- Flash Point: 7 ℃
- Hygroscopy: Highly hygroscopic, immediately hydrolyze when exposed to moisture in air
- Volatility: High volatility at room temperature
Chemical Properties
- Molecular structure: Acetal containing dimethylamino group, strong methylenation and formylation reagent
- Hydrolysis reaction: Rapidly decompose in presence of water to generate DMF and methanol, release heat
- Methylenation reaction: React with active methylene compounds to produce enaminone, methylidene derivatives
- Ester/Amide methylation: Methylate carboxylic acids, amines, phenols under mild conditions
- Formylation: Provide one-carbon unit for heterocyclic ring construction
- Thermal stability: Stable under normal temperature sealed storage; above 120 ℃ slow decomposition
- Compatibility: Only compatible with anhydrous aprotic solvents; strictly isolated from water, alcohol with high water content, acid
3. Main Application Fields
1. Organic Synthetic Methylenation Reagent (Core Application)
- Key reagent for synthesis of pharmaceutical heterocyclic intermediates (pyrimidine, pyrazole, triazole)
- Enaminone preparation for APIs, pesticides, fine chemical monomers
2. Methylation Modification Reagent
Methyl protection of carboxylic acid, phenol, secondary amine in multi-step synthesis
3. Spectroscopy Derivatization Reagent
Derivatization agent for GC/LC detection of carboxylic acid, amino compounds
4. Pharmaceutical Intermediate Custom Synthesis
Raw material for anti-viral, anti-inflammatory, cardiovascular drug intermediate production
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 4637-24-5 |
| Molecular Formula | C5H13NO2 |
| Molecular Weight | 119.16 |
| Appearance | Colorless transparent liquid |
| GC Purity | Synthetic Grade ≥98.0%; High Purity Grade ≥99.0% |
| Moisture Content | ≤0.05% |
| Color (APHA) | ≤15 |
| Heavy Metals (Pb) | ≤10 ppm |
| Bulk Package | 200L nitrogen-sealed plastic-lined iron drum / 25kg anhydrous plastic barrel |
| Storage Condition | Hermetic anhydrous nitrogen-filled warehouse ≤20℃; completely isolate air, moisture, acidic substances |
| Transportation Rule | Highly flammable dangerous liquid, anhydrous sealed anti-leakage fireproof packaging |
| Shelf Life | 12 months under intact anhydrous nitrogen packaging |
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