Shandong Huashang Chemical Co., Ltd. is a high-tech enterprise focused on industry of fine chemicals research and develop, produce and sale. Shandong Huashang Chemical Co., Ltd. is located in Shan Dong Ji Nan China. we have the ability to provide you high quality products. More than 90 % of our products are exported to developed countries and regions such as north America, Europe, Japan, South Korea and the Middle East.
1. Basic Information
Name: Gramicidin C
Alias: Gramicidin S
CAS No.: 113-73-5
Molecular Formula: C60H92N12O10
Molecular Weight: 1141.45
Amino acid sequence: Cyclo(-Val-Orn-Leu-D-Phe-Pro-Val-Orn-Leu-D-Phe-Pro-)?, symmetric cyclic decapeptide
2. Physical and Chemical Properties
Physical Properties
- Appearance: White to off-white crystalline powder; its hydrochloride salt forms colorless needle crystals
- Odor: Odorless
- Solubility: Insoluble in water; soluble in DMSO, methanol, ethanol and 70% ethanol solution; slightly soluble in acetone; insoluble in alkanes and ethers
- Melting Point: 265–270 °C (decomposes upon melting)
- Specific Rotation: [α]D2? ?292° ~ ?295° (c=1.5, 70% EtOH)
- Estimated Density: 1.24 g/cm3
- Hygroscopicity: Non-hygroscopic under normal ambient humidity
- LogP: 4.71, amphipathic molecular structure with hydrophobic region and cationic hydrophilic region
Chemical Properties
- Molecular structure: Cyclic β-sheet cationic polypeptide with two positively charged ornithine side chains, which can insert into bacterial lipid bilayers and destroy membrane integrity
- Antibacterial mechanism: Mainly acts on Gram-positive bacteria by disrupting ion transport of cell membranes and inhibiting Na?/K?-ATPase to induce bacterial lysis; presents weak inhibitory effect on Gram-negative bacteria
- Acid-base characteristic: Alkaline polypeptide that can form stable hydrochloride salts with inorganic acids
- Thermal stability: Stable below 240 °C; thermal decomposition occurs above melting point to break cyclic peptide backbone
- Photostability: Slightly sensitive to ultraviolet light; long-term light exposure causes slight discoloration
- Compatibility: Miscible with polar organic solvents; incompatible with strong oxidants and strong alkaline heating systems
3. Main Application Fields
1. Biochemical Research Reagent (Core Application)
- Research tool for cell membrane ion channel studies and inhibitor of ATPase activity for cell and molecular biology experiments
- Model polypeptide for antibacterial mechanism research in pharmaceutical antibacterial screening assays
2. Reference Standard for Microbial and Forensic Testing
HPLC/LC-MS calibration standard for quantitative detection of cyclic peptide antibiotics in microbial samples
3. Topical Antibacterial Raw Material (Historical Application)
Previously applied for external anti-infection of skin and wounds; high systemic toxicity prohibits oral and injection administration, and clinical usage is limited at present
4. Antimicrobial Lead Compound for New Drug Development
Template molecule for designing novel low-toxicity cationic polypeptide antibiotics via structural modification
4. Quality Specification Table
| Test Item | Standard Index |
| CAS Number | 113-73-5 |
| Molecular Formula | C60H92N12O10 |
| Molecular Weight | 1141.45 |
| Appearance | White to off-white crystalline powder |
| HPLC Purity | Research Grade ≥99.0%; Reference Standard ≥99.5% |
| Water Content (KF) | ≤0.20% |
| Residue on Ignition | ≤0.10% |
| Heavy Metals (Pb) | ≤10 ppm |
| Packaging Specification | 25kg fiber drum lined with PE film, amber aluminum foil vacuum bag filled with nitrogen |
| Storage Condition | Hermetic, light-proof, dry warehouse below 25 °C; avoid direct sunlight and humid air |
| Transportation Requirement | Bioactive polypeptide solid, sealed packaging with light and moisture resistance |
| Shelf Life | 24 months under intact nitrogen-filled light-proof vacuum packaging |
...
Product
